6-(2-fluorobenzyloxy)-1,3-dihydro-1-hydroxy-2,1-benzoxaborole

Base Information

Chemical Name:6-(2-fluorobenzyloxy)-1,3-dihydro-1-hydroxy-2,1-benzoxaborole
CAS No.:1222010-58-3
Molecular Formula:C₁₄H₁₂BFO₃
Molecular Weight:258.057
Hs Code.:

Synonyms:6-(2-fluorobenzyloxy)-1,3-dihydro-1-hydroxy-2,1-benzoxaborole

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Chemical Property of 6-(2-fluorobenzyloxy)-1,3-dihydro-1-hydroxy-2,1-benzoxaborole

Chemical Property:

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Technology Process of 6-(2-fluorobenzyloxy)-1,3-dihydro-1-hydroxy-2,1-benzoxaborole

There total 9 articles about 6-(2-fluorobenzyloxy)-1,3-dihydro-1-hydroxy-2,1-benzoxaborole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.7%

: 1196473-37-6
6-hydroxyl-1,3-dihydro-1-hydroxy-2,1-benzoxaborole

: 345-35-7
2-fluorobenzyl chloride

: 1222010-58-3
6-(2-fluorobenzyloxy)-1,3-dihydro-1-hydroxy-2,1-benzoxaborole

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jm101225g

Reference yield:

: 59142-68-6
2-bromo-4-fluorobenzaldehyde

: 1222010-58-3
6-(2-fluorobenzyloxy)-1,3-dihydro-1-hydroxy-2,1-benzoxaborole

Guidance literature:: Multi-step reaction with 6 steps

1.1: toluene-4-sulfonic acid / toluene / 4 h / Reflux

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 4 h / 65 °C / Cooling; Inert atmosphere

3.1: n-butyllithium; Triisopropyl borate / tetrahydrofuran / -80 - 20 °C / Inert atmosphere

3.2: 2 h

4.1: sodium tetrahydroborate / tetrahydrofuran / 1 h / 0 °C

5.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 0 °C / Inert atmosphere

With sodium tetrahydroborate; n-butyllithium; Triisopropyl borate; palladium 10% on activated carbon; hydrogen; sodium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.1021/jm101225g

Reference yield:

: 1222010-47-0
6-benzyloxy-1,3-dihydro-1-hydroxy-2,1-benzoxaborole

: 1222010-58-3
6-(2-fluorobenzyloxy)-1,3-dihydro-1-hydroxy-2,1-benzoxaborole

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

2: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 0 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; sodium hydride; In methanol; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm101225g