6-benzyloxy-1,3-dihydro-1-hydroxy-2,1-benzoxaborole

Base Information

• Chemical Name: 6-benzyloxy-1,3-dihydro-1-hydroxy-2,1-benzoxaborole
• CAS No.: 1222010-47-0
• Molecular Formula: C₁₄H₁₃BO₃
• Molecular Weight: 240.066
• Mol file: 1222010-47-0.mol

Synonyms:6-benzyloxy-1,3-dihydro-1-hydroxy-2,1-benzoxaborole

Chemical Property of 6-benzyloxy-1,3-dihydro-1-hydroxy-2,1-benzoxaborole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-benzyloxy-1,3-dihydro-1-hydroxy-2,1-benzoxaborole

There total 11 articles about 6-benzyloxy-1,3-dihydro-1-hydroxy-2,1-benzoxaborole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(5-(benzyloxy)-2-formylphenyl)boronic acid (1226773-36-9) → 6-benzyloxy-1,3-dihydro-1-hydroxy-2,1-benzoxaborole (1222010-47-0)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; at 0 ℃; for 1h;

DOI:10.1021/jm101225g

Reference yield: 66.0%

2-((4-(benzyloxy)-2-bromobenzyl)oxy)tetrahydro-2H-pyran (1222010-85-6) → 6-benzyloxy-1,3-dihydro-1-hydroxy-2,1-benzoxaborole (1222010-47-0)

Guidance literature:

2-((4-(benzyloxy)-2-bromobenzyl)oxy)tetrahydro-2H-pyran; With n-butyllithium; Triisopropyl borate; In tetrahydrofuran; at -80 - 20 ℃;

With hydrogenchloride; In tetrahydrofuran; water;

Reference yield: 48.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 3-(benzyloxy)phenylboronic acid (156682-54-1) → 6-benzyloxy-1,3-dihydro-1-hydroxy-2,1-benzoxaborole (1222010-47-0)

Guidance literature:

With trifluoroacetic acid; In chloroform; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1021/acs.orglett.1c00032

upstream raw materials:

2-((4-(benzyloxy)-2-bromobenzyl)oxy)tetrahydro-2H-pyran

(5-(benzyloxy)-2-formylphenyl)boronic acid

2-(2-bromo-4-fluorophenyl)-1,3-dioxolane

C₁₆H₁₅BrO₃

Downstream raw materials:

6-hydroxyl-1,3-dihydro-1-hydroxy-2,1-benzoxaborole

1,3-dihydro-1-hydroxy-2,2-benzoxaborol-6-yl N-phenylcarbamate

6-(2-fluorobenzyloxy)-1,3-dihydro-1-hydroxy-2,1-benzoxaborole

6-cyclohexylmethoxy-1,3-dihydro-1-hydroxy-2,1-benzoxaborole