N^α-tert-butoxycarbonyl-N^ε-(1-benzyloxy-1,2-dihydro-2-oxopyrimidin-4-yl)-L-lysyl-β-alanine

Base Information

• Chemical Name: N^α-tert-butoxycarbonyl-N^ε-(1-benzyloxy-1,2-dihydro-2-oxopyrimidin-4-yl)-L-lysyl-β-alanine
• CAS No.: 522644-16-2
• Molecular Formula: C₂₅H₃₅N₅O₇
• Molecular Weight: 517.582

Synonyms:N^α-tert-butoxycarbonyl-N^ε-(1-benzyloxy-1,2-dihydro-2-oxopyrimidin-4-yl)-L-lysyl-β-alanine

Chemical Property of N^α-tert-butoxycarbonyl-N^ε-(1-benzyloxy-1,2-dihydro-2-oxopyrimidin-4-yl)-L-lysyl-β-alanine

Chemical Property:

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Technology Process of N^α-tert-butoxycarbonyl-N^ε-(1-benzyloxy-1,2-dihydro-2-oxopyrimidin-4-yl)-L-lysyl-β-alanine

There total 5 articles about N^α-tert-butoxycarbonyl-N^ε-(1-benzyloxy-1,2-dihydro-2-oxopyrimidin-4-yl)-L-lysyl-β-alanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

Nα-tert-butoxycarbonyl-Nε-(1-benzyloxy-1,2-dihydro-2-oxopyrimidin-4-yl)-L-lysyl-β-alanine methyl ester (522644-15-1) → Nα-tert-butoxycarbonyl-Nε-(1-benzyloxy-1,2-dihydro-2-oxopyrimidin-4-yl)-L-lysyl-β-alanine (522644-16-2)

Guidance literature:

With sodium hydroxide; In methanol; at 20 ℃;

DOI:10.3987/COM-02-S(M)34

Reference yield:

N-α-(tert-butoxycarbonyl)-L-lysine methyl ester (55757-60-3) → Nα-tert-butoxycarbonyl-Nε-(1-benzyloxy-1,2-dihydro-2-oxopyrimidin-4-yl)-L-lysyl-β-alanine (522644-16-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 83 percent / CH₂Cl₂ / 144 h / 40 °C

2: 98 percent / aq. NaOH / methanol / 3 h / 20 °C

3: 87 percent / N-methylmorpholine; HOBt*H₂O; WSC*HCl / CH₂Cl₂ / 50 h / 0 - 20 °C

4: 85 percent / aq. NaOH / methanol / 20 °C

With 4-methyl-morpholine; sodium hydroxide; WSC*HCl; benzotriazol-1-ol; In methanol; dichloromethane;

DOI:10.3987/COM-02-S(M)34

Reference yield:

1-(benzyloxy)-4-(1′,2′,4′-triazol-1′-yl)-2-(1H)-pyrimidinone (219992-65-1) → Nα-tert-butoxycarbonyl-Nε-(1-benzyloxy-1,2-dihydro-2-oxopyrimidin-4-yl)-L-lysyl-β-alanine (522644-16-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 83 percent / CH₂Cl₂ / 144 h / 40 °C

2: 98 percent / aq. NaOH / methanol / 3 h / 20 °C

3: 87 percent / N-methylmorpholine; HOBt*H₂O; WSC*HCl / CH₂Cl₂ / 50 h / 0 - 20 °C

4: 85 percent / aq. NaOH / methanol / 20 °C

With 4-methyl-morpholine; sodium hydroxide; WSC*HCl; benzotriazol-1-ol; In methanol; dichloromethane;

DOI:10.3987/COM-02-S(M)34

upstream raw materials:

N^α-tert-butoxycarbonyl-N^ε-(1-benzyloxy-1,2-dihydro-2-oxopyrimidin-4-yl)-L-lysyl-β-alanine methyl ester

N-α-(tert-butoxycarbonyl)-L-lysine methyl ester

1-(benzyloxy)-4-(1′,2′,4′-triazol-1′-yl)-2-(1H)-pyrimidinone

N^α-tert-butoxycarbonyl-N^ε-(1-benzyloxy-1,2-dihydro-2-oxopyrimidin-4-yl)-L-lysine

Downstream raw materials:

N^α-tert-butoxycarbonyl-N^ε-(1-benzyloxy-1,2-dihydro-2-oxopyrimidin-4-yl)-L-lysyl-β-alanyl-N^ε-(1-benzyloxy-1,2-dihydro-2-oxopyrimidin-4-yl)-L-lysyl-β-alanine methyl ester

N^α-tert-butoxycarbonyl-N^ε-(1-benzyloxy-1,2-dihydro-2-oxopyrimidin-4-yl)-L-lysyl-β-alanyl N^ε-(1-benzyloxy-1,2-dihydro-2-oxopyrimidin-4-yl)-L-lysyl-β-alanyl-N^ε-(1-benzyloxy-1,2-dihydro-2-oxopyrimidin-4-yl)-L-lysyl-β-alanine methyl ester

C₆₅H₈₅N₁₅O₁₅

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