1-{4-[2-(4-bromophenyl)-1,3-dioxolan-2-yl]piperidin-1-yl}-2,2,2-trifluoroethanone

Base Information

Chemical Name:1-{4-[2-(4-bromophenyl)-1,3-dioxolan-2-yl]piperidin-1-yl}-2,2,2-trifluoroethanone
CAS No.:203187-77-3
Molecular Formula:C₁₆H₁₇BrF₃NO₃
Molecular Weight:408.215
Hs Code.:

Synonyms:1-{4-[2-(4-bromophenyl)-1,3-dioxolan-2-yl]piperidin-1-yl}-2,2,2-trifluoroethanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-{4-[2-(4-bromophenyl)-1,3-dioxolan-2-yl]piperidin-1-yl}-2,2,2-trifluoroethanone

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-{4-[2-(4-bromophenyl)-1,3-dioxolan-2-yl]piperidin-1-yl}-2,2,2-trifluoroethanone

There total 3 articles about 1-{4-[2-(4-bromophenyl)-1,3-dioxolan-2-yl]piperidin-1-yl}-2,2,2-trifluoroethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 107-21-1
ethylene glycol

: 203186-01-0
1-[4-(4-bromobenzoyl)piperidin-1-yl]-2,2,2-trifluoroethanone

: 203187-77-3
1-{4-[2-(4-bromophenyl)-1,3-dioxolan-2-yl]piperidin-1-yl}-2,2,2-trifluoroethanone

Guidance literature:: With toluene-4-sulfonic acid; In toluene; Heating;
DOI:10.1021/jm015526o

Reference yield:

: 498-94-2
isonipecotic acid

: 203187-77-3
1-{4-[2-(4-bromophenyl)-1,3-dioxolan-2-yl]piperidin-1-yl}-2,2,2-trifluoroethanone

Guidance literature:: Multi-step reaction with 4 steps

1: 4 h / Heating

2: SOCl₂ / Heating

3: AlCl₃ / 4 h / Heating

4: p-TsOH / Heating

With aluminium trichloride; thionyl chloride; toluene-4-sulfonic acid; 3: Friedel-Crafts acylation;
DOI:10.1021/jm0200815

Reference yield:

: 126501-70-0
1-(2,2,2-trifluoroacetyl)piperidine-4-carboxylic acid

: 203187-77-3
1-{4-[2-(4-bromophenyl)-1,3-dioxolan-2-yl]piperidin-1-yl}-2,2,2-trifluoroethanone

Guidance literature:: Multi-step reaction with 3 steps

1: SOCl₂ / Heating

2: AlCl₃ / 4 h / Heating

3: p-TsOH / Heating

With aluminium trichloride; thionyl chloride; toluene-4-sulfonic acid; 2: Friedel-Crafts acylation;
DOI:10.1021/jm0200815