Technology Process of 2-(1-methyl-3-benzyl-2-oxo-2,3-dihydro-1H-indol-3-yl)acetic acid
There total 8 articles about 2-(1-methyl-3-benzyl-2-oxo-2,3-dihydro-1H-indol-3-yl)acetic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
trifuran-2-yl-phosphane; palladium diacetate; potassium hydroxide;
In
1,4-dioxane; water;
at 80 ℃;
for 1h;
Inert atmosphere;
DOI:10.1021/acs.joc.5b01126
- Guidance literature:
-
methyl 2-(1-methyl-3-benzyl-2-oxo-2,3-dihydro-1H-indol-3-yl)acetate;
With
water; sodium hydroxide;
In
methanol;
at 50 ℃;
for 1.5h;
With
hydrogenchloride;
In
methanol; water;
at 0 ℃;
pH=1;
DOI:10.1016/j.tetasy.2009.09.017
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / 0 °C / Inert atmosphere
1.2: 24 h / Inert atmosphere; Reflux
2.1: sodium hydroxide / tetrahydrofuran; mineral oil; methanol / 1 h / 90 °C / Inert atmosphere
3.1: diethylamine / ethyl acetate / 0 °C / Inert atmosphere; Reflux
4.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.5 h / 20 °C / Inert atmosphere
5.1: dmap; triethylamine / dichloromethane / -20 - 20 °C / Inert atmosphere
6.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / 0 °C / Inert atmosphere
6.2: 20 - 50 °C / Inert atmosphere
7.1: potassium hydroxide; palladium diacetate; trifuran-2-yl-phosphane / water; 1,4-dioxane / 1 h / 80 °C / Inert atmosphere
With
dmap; oxalyl dichloride; trifuran-2-yl-phosphane; palladium diacetate; sodium hydride; diethylamine; triethylamine; N,N-dimethyl-formamide; potassium hydroxide; sodium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; ethyl acetate; mineral oil;
DOI:10.1021/acs.joc.5b01126
