tert-butyl 2-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)thiazol-4-ylcarbamate

Base Information

Chemical Name:tert-butyl 2-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)thiazol-4-ylcarbamate
CAS No.:1315566-69-8
Molecular Formula:C₁₉H₂₂N₄O₃S
Molecular Weight:386.475
Hs Code.:

Synonyms:tert-butyl 2-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)thiazol-4-ylcarbamate

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Chemical Property of tert-butyl 2-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)thiazol-4-ylcarbamate

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Technology Process of tert-butyl 2-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)thiazol-4-ylcarbamate

There total 8 articles about tert-butyl 2-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)thiazol-4-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1315566-68-7
2-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)thiazole-4-carboxylic acid

: 75-65-0
tert-butyl alcohol

: 1315566-69-8
tert-butyl 2-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)thiazol-4-ylcarbamate

Guidance literature:: With diphenyl phosphoryl azide; triethylamine; at 80 ℃; for 12h;

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 1315566-69-8
tert-butyl 2-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)thiazol-4-ylcarbamate

Guidance literature:: Multi-step reaction with 8 steps

1.1: acetonitrile / 4 h / 20 °C / Reflux

2.1: lithium hydroxide / water; tetrahydrofuran; methanol / 20 - 60 °C

2.2: pH 1 - 2

3.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.5 h / 20 °C

4.1: ammonia / dichloromethane; water / 0 °C

5.1: Lawessons reagent / toluene; chloroform / 12 h / 85 °C

6.1: pyridine / acetone / 54 h / 20 - 45 °C

7.1: sodium hydroxide / ethanol; water / 0 - 50 °C

7.2: acid

8.1: triethylamine; diphenyl phosphoryl azide / 12 h / 80 °C

With Lawessons reagent; pyridine; oxalyl dichloride; diphenyl phosphoryl azide; ammonia; triethylamine; sodium hydroxide; lithium hydroxide; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform; water; acetone; toluene; acetonitrile; 8.1: Curtius Rearrangement;

Reference yield:

: 1-(4-methoxybenzyl)-1H-pyrazole-4-carboxylic acid ethyl ester

: 1315566-69-8
tert-butyl 2-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)thiazol-4-ylcarbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium hydroxide / water; tetrahydrofuran; methanol / 20 - 60 °C

1.2: pH 1 - 2

2.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.5 h / 20 °C

3.1: ammonia / dichloromethane; water / 0 °C

4.1: Lawessons reagent / toluene; chloroform / 12 h / 85 °C

5.1: pyridine / acetone / 54 h / 20 - 45 °C

6.1: sodium hydroxide / ethanol; water / 0 - 50 °C

6.2: acid

7.1: triethylamine; diphenyl phosphoryl azide / 12 h / 80 °C

With Lawessons reagent; pyridine; oxalyl dichloride; diphenyl phosphoryl azide; ammonia; triethylamine; sodium hydroxide; lithium hydroxide; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform; water; acetone; toluene; 7.1: Curtius Rearrangement;