N-{[5-(2,6-dimethoxyphenyl)-1-(4-{[[3-(dimethylamino)propyl](methyl)amino]carbonyl}-2-isopropylphenyl)-1H-pyrazol-3-yl]carbonyl}-L-tyrosine

Base Information

Chemical Name:N-{[5-(2,6-dimethoxyphenyl)-1-(4-{[[3-(dimethylamino)propyl](methyl)amino]carbonyl}-2-isopropylphenyl)-1H-pyrazol-3-yl]carbonyl}-L-tyrosine
CAS No.:1476068-57-1
Molecular Formula:C₃₇H₄₅N₅O₇
Molecular Weight:671.794
Hs Code.:

Synonyms:N-{[5-(2,6-dimethoxyphenyl)-1-(4-{[[3-(dimethylamino)propyl](methyl)amino]carbonyl}-2-isopropylphenyl)-1H-pyrazol-3-yl]carbonyl}-L-tyrosine

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Chemical Property of N-{[5-(2,6-dimethoxyphenyl)-1-(4-{[[3-(dimethylamino)propyl](methyl)amino]carbonyl}-2-isopropylphenyl)-1H-pyrazol-3-yl]carbonyl}-L-tyrosine

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Technology Process of N-{[5-(2,6-dimethoxyphenyl)-1-(4-{[[3-(dimethylamino)propyl](methyl)amino]carbonyl}-2-isopropylphenyl)-1H-pyrazol-3-yl]carbonyl}-L-tyrosine

There total 6 articles about N-{[5-(2,6-dimethoxyphenyl)-1-(4-{[[3-(dimethylamino)propyl](methyl)amino]carbonyl}-2-isopropylphenyl)-1H-pyrazol-3-yl]carbonyl}-L-tyrosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1476068-53-7
tert-butyl O-(tert-butyl)-N-{[5-(2,6-dimethoxyphenyl)-1-(4-{[[3-(dimethylamino)propyl](methyl)amino]carbonyl}-2-isopropylphenyl)-1H-pyrazol-3-yl]carbonyl}-L-tyrosinate

: 1476068-57-1
N-{[5-(2,6-dimethoxyphenyl)-1-(4-{[[3-(dimethylamino)propyl](methyl)amino]carbonyl}-2-isopropylphenyl)-1H-pyrazol-3-yl]carbonyl}-L-tyrosine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃;
DOI:10.1055/s-0033-1338497

Reference yield:

: 643-28-7
2-isopropylaniline

: 1476068-57-1
N-{[5-(2,6-dimethoxyphenyl)-1-(4-{[[3-(dimethylamino)propyl](methyl)amino]carbonyl}-2-isopropylphenyl)-1H-pyrazol-3-yl]carbonyl}-L-tyrosine

Guidance literature:: Multi-step reaction with 6 steps

1.1: ammonium acetate; N-Bromosuccinimide / acetonitrile / 0.17 h / 20 °C

2.1: hydrogenchloride; sodium nitrite / water / 0 °C

2.2: 0.5 h / 0 °C

2.3: 0.33 h / Reflux

3.1: trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); tri tert-butylphosphoniumtetrafluoroborate; 1,8-diazabicyclo[5.4.0]undec-7-ene / 1,4-dioxane / 0.5 h / 140 °C / Inert atmosphere; Sealed tube; Microwave irradiation

4.1: potassium hydroxide; water / 1,4-dioxane / 4 h / Reflux

5.1: triethylamine; isobutyl chloroformate / acetonitrile / 20 °C / Inert atmosphere

5.2: 5 h / 20 °C / Inert atmosphere

6.1: trifluoroacetic acid / dichloromethane / 20 °C

With hydrogenchloride; N-Bromosuccinimide; trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); ammonium acetate; water; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trifluoroacetic acid; potassium hydroxide; tri tert-butylphosphoniumtetrafluoroborate; sodium nitrite; isobutyl chloroformate; In 1,4-dioxane; dichloromethane; water; acetonitrile;
DOI:10.1055/s-0033-1338497

Reference yield:

: methyl 5-(2,6-dimethoxyphenyl)-1-(4-{[[3-(dimethylamino)propyl](methyl)amino]carbonyl}-2-isopropylphenyl)-1H-pyrazole-3-carboxylate

: 1476068-57-1
N-{[5-(2,6-dimethoxyphenyl)-1-(4-{[[3-(dimethylamino)propyl](methyl)amino]carbonyl}-2-isopropylphenyl)-1H-pyrazol-3-yl]carbonyl}-L-tyrosine

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide; water / 1,4-dioxane / 4 h / Reflux

2.1: triethylamine; isobutyl chloroformate / acetonitrile / 20 °C / Inert atmosphere

2.2: 5 h / 20 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 20 °C

With water; triethylamine; trifluoroacetic acid; potassium hydroxide; isobutyl chloroformate; In 1,4-dioxane; dichloromethane; acetonitrile;
DOI:10.1055/s-0033-1338497