tert-butyl O-(tert-butyl)-N-{[5-(2,6-dimethoxyphenyl)-1-(4-{[[3-(dimethylamino)propyl](methyl)amino]carbonyl}-2-isopropylphenyl)-1H-pyrazol-3-yl]carbonyl}-L-tyrosinate

Base Information

Chemical Name:tert-butyl O-(tert-butyl)-N-{[5-(2,6-dimethoxyphenyl)-1-(4-{[[3-(dimethylamino)propyl](methyl)amino]carbonyl}-2-isopropylphenyl)-1H-pyrazol-3-yl]carbonyl}-L-tyrosinate
CAS No.:1476068-53-7
Molecular Formula:C₄₅H₆₁N₅O₇
Molecular Weight:784.009
Hs Code.:

tert-butyl O-(tert-butyl)-N-{[5-(2,6-dimethoxyphenyl)-1-(4-{[[3-(dimethylamino)propyl](methyl)amino]carbonyl}-2-isopropylphenyl)-1H-pyrazol-3-yl]carbonyl}-L-tyrosinate

Synonyms:tert-butyl O-(tert-butyl)-N-{[5-(2,6-dimethoxyphenyl)-1-(4-{[[3-(dimethylamino)propyl](methyl)amino]carbonyl}-2-isopropylphenyl)-1H-pyrazol-3-yl]carbonyl}-L-tyrosinate

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Chemical Property of tert-butyl O-(tert-butyl)-N-{[5-(2,6-dimethoxyphenyl)-1-(4-{[[3-(dimethylamino)propyl](methyl)amino]carbonyl}-2-isopropylphenyl)-1H-pyrazol-3-yl]carbonyl}-L-tyrosinate

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Technology Process of tert-butyl O-(tert-butyl)-N-{[5-(2,6-dimethoxyphenyl)-1-(4-{[[3-(dimethylamino)propyl](methyl)amino]carbonyl}-2-isopropylphenyl)-1H-pyrazol-3-yl]carbonyl}-L-tyrosinate

There total 5 articles about tert-butyl O-(tert-butyl)-N-{[5-(2,6-dimethoxyphenyl)-1-(4-{[[3-(dimethylamino)propyl](methyl)amino]carbonyl}-2-isopropylphenyl)-1H-pyrazol-3-yl]carbonyl}-L-tyrosinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 5-(2,6-dimethoxyphenyl)-1-(4-{[[3-(dimethylamino)propyl](methyl)amino]carbonyl}-2-isopropylphenyl)-1H-pyrazole-3-carboxylic acid

: 17083-23-7
2-amino-3-(4-tert-butoxy-phenyl)-propionic acid tert-butyl ester

: 1476068-53-7
tert-butyl O-(tert-butyl)-N-{[5-(2,6-dimethoxyphenyl)-1-(4-{[[3-(dimethylamino)propyl](methyl)amino]carbonyl}-2-isopropylphenyl)-1H-pyrazol-3-yl]carbonyl}-L-tyrosinate

Guidance literature:: 5-(2,6-dimethoxyphenyl)-1-(4-{[[3-(dimethylamino)propyl](methyl)amino]carbonyl}-2-isopropylphenyl)-1H-pyrazole-3-carboxylic acid; With triethylamine; isobutyl chloroformate; In acetonitrile; at 20 ℃; Inert atmosphere;

2-amino-3-(4-tert-butoxy-phenyl)-propionic acid tert-butyl ester; With triethylamine; In acetonitrile; at 20 ℃; for 5h; Inert atmosphere;
DOI:10.1055/s-0033-1338497

Reference yield:

: methyl 5-(2,6-dimethoxyphenyl)-1-(4-{[[3-(dimethylamino)propyl](methyl)amino]carbonyl}-2-isopropylphenyl)-1H-pyrazole-3-carboxylate

: 1476068-53-7
tert-butyl O-(tert-butyl)-N-{[5-(2,6-dimethoxyphenyl)-1-(4-{[[3-(dimethylamino)propyl](methyl)amino]carbonyl}-2-isopropylphenyl)-1H-pyrazol-3-yl]carbonyl}-L-tyrosinate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium hydroxide; water / 1,4-dioxane / 4 h / Reflux

2.1: triethylamine; isobutyl chloroformate / acetonitrile / 20 °C / Inert atmosphere

2.2: 5 h / 20 °C / Inert atmosphere

With water; triethylamine; potassium hydroxide; isobutyl chloroformate; In 1,4-dioxane; acetonitrile;
DOI:10.1055/s-0033-1338497

Reference yield:

: 643-28-7
2-isopropylaniline

: 1476068-53-7
tert-butyl O-(tert-butyl)-N-{[5-(2,6-dimethoxyphenyl)-1-(4-{[[3-(dimethylamino)propyl](methyl)amino]carbonyl}-2-isopropylphenyl)-1H-pyrazol-3-yl]carbonyl}-L-tyrosinate

Guidance literature:: Multi-step reaction with 5 steps

1.1: ammonium acetate; N-Bromosuccinimide / acetonitrile / 0.17 h / 20 °C

2.1: hydrogenchloride; sodium nitrite / water / 0 °C

2.2: 0.5 h / 0 °C

2.3: 0.33 h / Reflux

3.1: trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); tri tert-butylphosphoniumtetrafluoroborate; 1,8-diazabicyclo[5.4.0]undec-7-ene / 1,4-dioxane / 0.5 h / 140 °C / Inert atmosphere; Sealed tube; Microwave irradiation

4.1: potassium hydroxide; water / 1,4-dioxane / 4 h / Reflux

5.1: triethylamine; isobutyl chloroformate / acetonitrile / 20 °C / Inert atmosphere

5.2: 5 h / 20 °C / Inert atmosphere

With hydrogenchloride; N-Bromosuccinimide; trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); ammonium acetate; water; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; potassium hydroxide; tri tert-butylphosphoniumtetrafluoroborate; sodium nitrite; isobutyl chloroformate; In 1,4-dioxane; water; acetonitrile;
DOI:10.1055/s-0033-1338497