2-(3-fluorophenylsulfonamido)-N-(4-methyl-3-(trifluoromethyl)phenyl)benzamide

Base Information

Chemical Name:2-(3-fluorophenylsulfonamido)-N-(4-methyl-3-(trifluoromethyl)phenyl)benzamide
CAS No.:1454274-91-9
Molecular Formula:C₂₁H₁₆F₄N₂O₃S
Molecular Weight:452.429
Hs Code.:

Synonyms:2-(3-fluorophenylsulfonamido)-N-(4-methyl-3-(trifluoromethyl)phenyl)benzamide

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Chemical Property of 2-(3-fluorophenylsulfonamido)-N-(4-methyl-3-(trifluoromethyl)phenyl)benzamide

Chemical Property:

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Technology Process of 2-(3-fluorophenylsulfonamido)-N-(4-methyl-3-(trifluoromethyl)phenyl)benzamide

There total 4 articles about 2-(3-fluorophenylsulfonamido)-N-(4-methyl-3-(trifluoromethyl)phenyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.8%

: 926187-40-8
2-(3-fluorophenylsulfonamido)benzoic acid

: 65934-74-9
3-(trifluoromethyl)-4-methylaniline

: 1454274-91-9
2-(3-fluorophenylsulfonamido)-N-(4-methyl-3-(trifluoromethyl)phenyl)benzamide

Guidance literature:: 2-(3-fluorophenylsulfonamido)benzoic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

3-(trifluoromethyl)-4-methylaniline; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 12h;
DOI:10.3390/molecules18066883

Reference yield:

: 701-27-9
3-fluorobenzene-1-sulfonyl chloride

: 1454274-91-9
2-(3-fluorophenylsulfonamido)-N-(4-methyl-3-(trifluoromethyl)phenyl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / tetrahydrofuran / 9 h / 20 °C

2.1: sodium hydroxide / ethanol; water / 8 h / 80 °C

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 2 h / 20 °C

3.2: 12 h / 20 °C

With pyridine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;
DOI:10.3390/molecules18066883

Reference yield:

: 134-20-3
2-carbomethoxyaniline

: 1454274-91-9
2-(3-fluorophenylsulfonamido)-N-(4-methyl-3-(trifluoromethyl)phenyl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / tetrahydrofuran / 9 h / 20 °C

2.1: sodium hydroxide / ethanol; water / 8 h / 80 °C

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 2 h / 20 °C

3.2: 12 h / 20 °C

With pyridine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;
DOI:10.3390/molecules18066883