5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-(1-hydroxy-2,2,2-trifluoroethyl)-4-methyl-1H-pyrazole

Base Information

Chemical Name:5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-(1-hydroxy-2,2,2-trifluoroethyl)-4-methyl-1H-pyrazole
CAS No.:1430408-27-7
Molecular Formula:C₁₈H₁₂Cl₃F₃N₂O
Molecular Weight:435.66
Hs Code.:

Synonyms:5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-(1-hydroxy-2,2,2-trifluoroethyl)-4-methyl-1H-pyrazole

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Chemical Property of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-(1-hydroxy-2,2,2-trifluoroethyl)-4-methyl-1H-pyrazole

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Technology Process of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-(1-hydroxy-2,2,2-trifluoroethyl)-4-methyl-1H-pyrazole

There total 5 articles about 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-(1-hydroxy-2,2,2-trifluoroethyl)-4-methyl-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 913624-97-2
5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxaldehyde

: 81290-20-2
(trifluoromethyl)trimethylsilane

: 1430408-27-7
5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-(1-hydroxy-2,2,2-trifluoroethyl)-4-methyl-1H-pyrazole

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1016/j.ejmech.2012.12.056

Reference yield:

: 169544-41-6
4-(4-chlorophenyl)-3-methyl-2,4-dioxobutyric acid ethyl ester

: 1430408-27-7
5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-(1-hydroxy-2,2,2-trifluoroethyl)-4-methyl-1H-pyrazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: ethanol / 16 h / Reflux

2.1: trimethylaluminum / hexane; dichloromethane / 1.42 h / 0 - 20 °C

2.2: 16 h / 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; tetrabutyl ammonium fluoride; trimethylaluminum; In tetrahydrofuran; ethanol; hexane; dichloromethane;
DOI:10.1016/j.ejmech.2012.12.056

Reference yield:

: 6285-05-8
4'-chloropropiophenone

: 1430408-27-7
5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-(1-hydroxy-2,2,2-trifluoroethyl)-4-methyl-1H-pyrazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium / ethanol / 18 h / 20 °C

2.1: ethanol / 16 h / Reflux

3.1: trimethylaluminum / hexane; dichloromethane / 1.42 h / 0 - 20 °C

3.2: 16 h / 20 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; tetrabutyl ammonium fluoride; trimethylaluminum; sodium; In tetrahydrofuran; ethanol; hexane; dichloromethane; 1.1: |Claisen Condensation;
DOI:10.1016/j.ejmech.2012.12.056