2-(3-benzylphenyl)propionic acid 3-chloro-2,2-dimethylpropyl ester

Base Information

• Chemical Name: 2-(3-benzylphenyl)propionic acid 3-chloro-2,2-dimethylpropyl ester
• CAS No.: 259878-91-6
• Molecular Formula: C₂₁H₂₅ClO₂
• Molecular Weight: 344.881
• Mol file: 259878-91-6.mol

Synonyms:2-(3-benzylphenyl)propionic acid 3-chloro-2,2-dimethylpropyl ester

Chemical Property of 2-(3-benzylphenyl)propionic acid 3-chloro-2,2-dimethylpropyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3-benzylphenyl)propionic acid 3-chloro-2,2-dimethylpropyl ester

There total 1 articles about 2-(3-benzylphenyl)propionic acid 3-chloro-2,2-dimethylpropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-(1-chloroethyl)-5,5-dimethyl-2-(3-benzylphenyl)-1,3-dioxane (259878-89-2) → 2-(3-benzylphenyl)propionic acid 3-chloro-2,2-dimethylpropyl ester (259878-91-6)

Guidance literature:

With zinc 2-(3-benzylphenyl)propionate; In toluene; for 3.5h; Heating;

Reference yield: 90.0%

2-(3-benzylphenyl)propionic acid 3-chloro-2,2-dimethylpropyl ester (259878-91-6) → α-(3-benzylphenyl)-propionic acid (22161-82-6,75116-79-9,75196-29-1,73913-48-1)

Guidance literature:

With sodium hydroxide; In methanol; for 3.5h; Heating;

Reference yield:

2-(3-benzylphenyl)propionic acid 3-chloro-2,2-dimethylpropyl ester (259878-91-6) → ketoprofen (22071-15-4,22161-86-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / aq. NaOH / methanol / 3.5 h / Heating

2: 86.5 percent / KMnO₄; Et₃N; H₂SO₄ / 1,2-dichloro-ethane; H₂O / 3.5 h / 20 °C

With sodium hydroxide; potassium permanganate; sulfuric acid; triethylamine; In methanol; water; 1,2-dichloro-ethane; 1: Hydrolysis / 2: Oxidation;

upstream raw materials:

2-(1-chloroethyl)-5,5-dimethyl-2-(3-benzylphenyl)-1,3-dioxane

Downstream raw materials:

α-(3-benzylphenyl)-propionic acid

ketoprofen