1-(1-benzenesulfonyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-3,3-dimethyl-butan-1-one

Base Information

Chemical Name:1-(1-benzenesulfonyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-3,3-dimethyl-butan-1-one
CAS No.:1312019-41-2
Molecular Formula:C₁₉H₂₀N₂O₃S
Molecular Weight:356.445
Hs Code.:

Synonyms:1-(1-benzenesulfonyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-3,3-dimethyl-butan-1-one

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Chemical Property of 1-(1-benzenesulfonyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-3,3-dimethyl-butan-1-one

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Technology Process of 1-(1-benzenesulfonyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-3,3-dimethyl-butan-1-one

There total 9 articles about 1-(1-benzenesulfonyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-3,3-dimethyl-butan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1312019-40-1
1-(1-benzenesulfonyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-3,3-dimethyl-butan-1-ol

: 1312019-41-2
1-(1-benzenesulfonyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-3,3-dimethyl-butan-1-one

Guidance literature:: With Dess-Martin periodane; In dichloromethane; at 25 ℃; for 2h;

Reference yield:

: 271-63-6
7-Azaindole

: 1312019-41-2
1-(1-benzenesulfonyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-3,3-dimethyl-butan-1-one

Guidance literature:: Multi-step reaction with 9 steps

1.1: triethylamine; formic acid / palladium 10% on activated carbon / 120 h / 0 - 80 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

2.2: 3 h / 0 °C

3.1: bromine; pyridine / dichloromethane / 2 h / 0 °C

4.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 1 h

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 25 °C

6.1: copper(I) bromide; sodium / N,N-dimethyl-formamide / 5 h / Inert atmosphere; Reflux

7.1: sodium hydroxide; tetrabutylammomium bromide / dichloromethane / 0.08 h / 0 °C

7.2: 12.25 h / 0 - 25 °C

8.1: n-butyllithium / hexane; tetrahydrofuran / 0.25 h / -78 °C

8.2: 1 h / -78 °C

9.1: Dess-Martin periodane / dichloromethane / 2 h / 25 °C

With pyridine; n-butyllithium; formic acid; tetrabutyl ammonium fluoride; tetrabutylammomium bromide; bromine; sodium; sodium hydride; Dess-Martin periodane; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; copper(I) bromide; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 183208-36-8
5-methoxy-1H-pyrrolo[2,3-b]pyridine

: 1312019-41-2
1-(1-benzenesulfonyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-3,3-dimethyl-butan-1-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide; tetrabutylammomium bromide / dichloromethane / 0.08 h / 0 °C

1.2: 12.25 h / 0 - 25 °C

2.1: n-butyllithium / hexane; tetrahydrofuran / 0.25 h / -78 °C

2.2: 1 h / -78 °C

3.1: Dess-Martin periodane / dichloromethane / 2 h / 25 °C

With n-butyllithium; tetrabutylammomium bromide; Dess-Martin periodane; sodium hydroxide; In tetrahydrofuran; hexane; dichloromethane;