(3S,6S)-(-)-6-(1-benzoyloxyindol-3-ylmethyl)-3-isobutyl-2,5-piperazinedione

Base Information

Chemical Name:(3S,6S)-(-)-6-(1-benzoyloxyindol-3-ylmethyl)-3-isobutyl-2,5-piperazinedione
CAS No.:403655-45-8
Molecular Formula:C₂₄H₂₅N₃O₄
Molecular Weight:419.48
Hs Code.:

Synonyms:(3S,6S)-(-)-6-(1-benzoyloxyindol-3-ylmethyl)-3-isobutyl-2,5-piperazinedione

Suppliers and Price of (3S,6S)-(-)-6-(1-benzoyloxyindol-3-ylmethyl)-3-isobutyl-2,5-piperazinedione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3S,6S)-(-)-6-(1-benzoyloxyindol-3-ylmethyl)-3-isobutyl-2,5-piperazinedione

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Technology Process of (3S,6S)-(-)-6-(1-benzoyloxyindol-3-ylmethyl)-3-isobutyl-2,5-piperazinedione

There total 7 articles about (3S,6S)-(-)-6-(1-benzoyloxyindol-3-ylmethyl)-3-isobutyl-2,5-piperazinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 98-88-4
benzoyl chloride

: 180910-60-5
(3S,6S)-(–)-6-(1-hydroxyindol-3-ylmethyl)-3-isobutyl-2,5-piperazinedione

: 403655-45-8
(3S,6S)-(-)-6-(1-benzoyloxyindol-3-ylmethyl)-3-isobutyl-2,5-piperazinedione

Guidance literature:: With pyridine;
DOI:10.3987/com-01-9334

Reference yield:

: 2419-36-5
Cbz-Trp-Leu-OMe

: 403655-45-8
(3S,6S)-(-)-6-(1-benzoyloxyindol-3-ylmethyl)-3-isobutyl-2,5-piperazinedione

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogen / 10 percent Pd/C

2: MeOH; Et₃N / Heating

3: 83 percent / Et₃SiH / trifluoroacetic acid

4: 63 percent / Na₂WO₄*2H₂O; aq. H₂O₂ / CH₂Cl₂; aq. methanol

5: 96 percent / pyridine

With pyridine; methanol; triethylsilane; sodium tungstate; hydrogen; dihydrogen peroxide; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; trifluoroacetic acid;
DOI:10.3987/com-01-9334

Reference yield:

: 2666-93-5
(S)-Leu-OMe

: 403655-45-8
(3S,6S)-(-)-6-(1-benzoyloxyindol-3-ylmethyl)-3-isobutyl-2,5-piperazinedione

Guidance literature:: Multi-step reaction with 6 steps

1: methyl chloroformate

2: hydrogen / 10 percent Pd/C

3: MeOH; Et₃N / Heating

4: 83 percent / Et₃SiH / trifluoroacetic acid

5: 63 percent / Na₂WO₄*2H₂O; aq. H₂O₂ / CH₂Cl₂; aq. methanol

6: 96 percent / pyridine

With pyridine; methanol; triethylsilane; sodium tungstate; hydrogen; dihydrogen peroxide; triethylamine; methyl chloroformate; palladium on activated charcoal; In methanol; dichloromethane; trifluoroacetic acid;
DOI:10.3987/com-01-9334