(R)-4-chloro-N-(1-(1-ethyl-6-(hydroxymethyl)-1H-benzo[d]imidazol-2-yl)ethyl)benzenesulfonamide

Base Information

Chemical Name:(R)-4-chloro-N-(1-(1-ethyl-6-(hydroxymethyl)-1H-benzo[d]imidazol-2-yl)ethyl)benzenesulfonamide
CAS No.:1025506-96-0
Molecular Formula:C₁₈H₂₀ClN₃O₃S
Molecular Weight:393.894
Hs Code.:

Synonyms:(R)-4-chloro-N-(1-(1-ethyl-6-(hydroxymethyl)-1H-benzo[d]imidazol-2-yl)ethyl)benzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-4-chloro-N-(1-(1-ethyl-6-(hydroxymethyl)-1H-benzo[d]imidazol-2-yl)ethyl)benzenesulfonamide

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Technology Process of (R)-4-chloro-N-(1-(1-ethyl-6-(hydroxymethyl)-1H-benzo[d]imidazol-2-yl)ethyl)benzenesulfonamide

There total 7 articles about (R)-4-chloro-N-(1-(1-ethyl-6-(hydroxymethyl)-1H-benzo[d]imidazol-2-yl)ethyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1025506-95-9
2-[(R)-1-(4-chloro-benzenesulfonylamino)-ethyl]-3-ethyl-3H-benzoimidazole-5-carboxylic acid ethyl ester

: 1025506-96-0
(R)-4-chloro-N-(1-(1-ethyl-6-(hydroxymethyl)-1H-benzo[d]imidazol-2-yl)ethyl)benzenesulfonamide

Guidance literature:: 2-[(R)-1-(4-chloro-benzenesulfonylamino)-ethyl]-3-ethyl-3H-benzoimidazole-5-carboxylic acid ethyl ester; With diisobutylaluminium hydride; In tetrahydrofuran; at 0 - 20 ℃;

With methanol; In tetrahydrofuran;

Reference yield:

: C₁₂H₁₇N₃O

: 98-60-2
4-chlorobenzenesulfonyl chloride

: 1025506-96-0
(R)-4-chloro-N-(1-(1-ethyl-6-(hydroxymethyl)-1H-benzo[d]imidazol-2-yl)ethyl)benzenesulfonamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 2h;
DOI:10.1021/acs.jmedchem.5b01078

Reference yield:

: 113372-68-2
3-chloro-4-nitrobenzyl alcohol

: 1025506-96-0
(R)-4-chloro-N-(1-(1-ethyl-6-(hydroxymethyl)-1H-benzo[d]imidazol-2-yl)ethyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1: 2 h / Microwave irradiation; Sealed tube

2: palladium 10% on activated carbon; hydrogen / ethanol / 20 °C / 760.05 Torr / Inert atmosphere

3: triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 0 - 20 °C

4: acetic acid / 2 h / 65 °C

5: hydrogenchloride / water; 1,4-dioxane / 2 h / 20 °C

6: triethylamine / dichloromethane / 2 h / 0 °C

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; acetic acid; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.5b01078