4-chloro-N-[(R)-1-(1-ethyl-6-formyl-1H-benzoimidazol-2-yl)ethyl]benzenesulfonamide

Base Information

• Chemical Name: 4-chloro-N-[(R)-1-(1-ethyl-6-formyl-1H-benzoimidazol-2-yl)ethyl]benzenesulfonamide
• CAS No.: 1025508-15-9
• Molecular Formula: C₁₈H₁₈ClN₃O₃S
• Molecular Weight: 391.878

Synonyms:4-chloro-N-[(R)-1-(1-ethyl-6-formyl-1H-benzoimidazol-2-yl)ethyl]benzenesulfonamide

Chemical Property of 4-chloro-N-[(R)-1-(1-ethyl-6-formyl-1H-benzoimidazol-2-yl)ethyl]benzenesulfonamide

Chemical Property:

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Technology Process of 4-chloro-N-[(R)-1-(1-ethyl-6-formyl-1H-benzoimidazol-2-yl)ethyl]benzenesulfonamide

There total 1 articles about 4-chloro-N-[(R)-1-(1-ethyl-6-formyl-1H-benzoimidazol-2-yl)ethyl]benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(R)-4-chloro-N-(1-(1-ethyl-6-(hydroxymethyl)-1H-benzo[d]imidazol-2-yl)ethyl)benzenesulfonamide (1025506-96-0) → 4-chloro-N-[(R)-1-(1-ethyl-6-formyl-1H-benzoimidazol-2-yl)ethyl]benzenesulfonamide (1025508-15-9)

Guidance literature:

With manganese(IV) oxide; In acetone; at 18 - 25 ℃;

Reference yield: 14.0%

4-chloro-N-[(R)-1-(1-ethyl-6-formyl-1H-benzoimidazol-2-yl)ethyl]benzenesulfonamide (1025508-15-9) → 4-chloro-N-[(R)-1-(6-difluoromethyl-1-ethyl-1H-benzoimidazol-2-yl)-ethyl]-benzenesulfonamide (1025506-97-1)

Guidance literature:

With diethylamino-sulfur trifluoride; In chloroform; at 60 ℃;

Reference yield:

4-chloro-N-[(R)-1-(1-ethyl-6-formyl-1H-benzoimidazol-2-yl)ethyl]benzenesulfonamide (1025508-15-9) + dimethyl amine (124-40-3) → (R)-4-chloro-N-(1-(6-((dimethylamino)methyl)-1-ethyl-1Hbenzo[d]imidazol-2-yl)ethyl)benzenesulfonamide (1025507-02-1)

Guidance literature:

With sodium tris(acetoxy)borohydride; In tetrahydrofuran; at 18 - 25 ℃;

upstream raw materials:

(R)-4-chloro-N-(1-(1-ethyl-6-(hydroxymethyl)-1H-benzo[d]imidazol-2-yl)ethyl)benzenesulfonamide

Downstream raw materials:

(R)-4-chloro-N-(1-(6-((dimethylamino)methyl)-1-ethyl-1Hbenzo[d]imidazol-2-yl)ethyl)benzenesulfonamide

4-chloro-N-[(R)-1-(6-difluoromethyl-1-ethyl-1H-benzoimidazol-2-yl)-ethyl]-benzenesulfonamide

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