1-benzyl-6-chloro-3-[2-(diethylamino)ethyl]-2,3-dihydro-4(1H)-quinazolinone

Base Information

Chemical Name:1-benzyl-6-chloro-3-[2-(diethylamino)ethyl]-2,3-dihydro-4(1H)-quinazolinone
CAS No.:159794-04-4
Molecular Formula:C₂₁H₂₆ClN₃O
Molecular Weight:371.91
Hs Code.:

Synonyms:1-benzyl-6-chloro-3-[2-(diethylamino)ethyl]-2,3-dihydro-4(1H)-quinazolinone

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Chemical Property of 1-benzyl-6-chloro-3-[2-(diethylamino)ethyl]-2,3-dihydro-4(1H)-quinazolinone

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Technology Process of 1-benzyl-6-chloro-3-[2-(diethylamino)ethyl]-2,3-dihydro-4(1H)-quinazolinone

There total 4 articles about 1-benzyl-6-chloro-3-[2-(diethylamino)ethyl]-2,3-dihydro-4(1H)-quinazolinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 100-39-0
benzyl bromide

: 159793-94-9
6-chloro-3-[2-(diethylamino)ethyl]-2,3-dihydro-4(1H)-quinazolinone

: 159794-04-4
1-benzyl-6-chloro-3-[2-(diethylamino)ethyl]-2,3-dihydro-4(1H)-quinazolinone

Guidance literature:: With sodium hydride; In dimethyl sulfoxide; toluene; at 40 ℃; for 2h;

Reference yield:

: 4743-17-3
5-Chloroisatoic anhydride

: 159794-04-4
1-benzyl-6-chloro-3-[2-(diethylamino)ethyl]-2,3-dihydro-4(1H)-quinazolinone

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / dioxane / 2 h / 60 °C

2: 2.) 80percent w/v NaOH / 1.) ethanol/water, reflux, 1 h; 2.) ethanol/water, reflux, 20 min

3: 71 percent / sodium hydride (95percent) / dimethylsulfoxide; toluene / 2 h / 40 °C

With sodium hydroxide; sodium hydride; In 1,4-dioxane; dimethyl sulfoxide; toluene;

Reference yield:

: 30646-50-5
2-amino-5-chloro-N-[2-(diethylamino)ethyl] benzamide

: 159794-04-4
1-benzyl-6-chloro-3-[2-(diethylamino)ethyl]-2,3-dihydro-4(1H)-quinazolinone

Guidance literature:: Multi-step reaction with 2 steps

1: 2.) 80percent w/v NaOH / 1.) ethanol/water, reflux, 1 h; 2.) ethanol/water, reflux, 20 min

2: 71 percent / sodium hydride (95percent) / dimethylsulfoxide; toluene / 2 h / 40 °C

With sodium hydroxide; sodium hydride; In dimethyl sulfoxide; toluene;