N-({3-[(3-{[(5-chloro-2-thienyl)sulfonyl]amino}-4-cyano-1H-indazol-1-yl)methyl]phenyl}methyl)acetamide

Base Information

Chemical Name:N-({3-[(3-{[(5-chloro-2-thienyl)sulfonyl]amino}-4-cyano-1H-indazol-1-yl)methyl]phenyl}methyl)acetamide
CAS No.:1240518-65-3
Molecular Formula:C₂₂H₁₈ClN₅O₃S₂
Molecular Weight:500.002
Hs Code.:

Synonyms:N-({3-[(3-{[(5-chloro-2-thienyl)sulfonyl]amino}-4-cyano-1H-indazol-1-yl)methyl]phenyl}methyl)acetamide

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Chemical Property of N-({3-[(3-{[(5-chloro-2-thienyl)sulfonyl]amino}-4-cyano-1H-indazol-1-yl)methyl]phenyl}methyl)acetamide

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Technology Process of N-({3-[(3-{[(5-chloro-2-thienyl)sulfonyl]amino}-4-cyano-1H-indazol-1-yl)methyl]phenyl}methyl)acetamide

There total 14 articles about N-({3-[(3-{[(5-chloro-2-thienyl)sulfonyl]amino}-4-cyano-1H-indazol-1-yl)methyl]phenyl}methyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.0%

: 1240518-84-6
C₂₀H₁₆ClN₅O₂S₂

: 108-24-7
acetic anhydride

: 1240518-65-3
N-({3-[(3-{[(5-chloro-2-thienyl)sulfonyl]amino}-4-cyano-1H-indazol-1-yl)methyl]phenyl}methyl)acetamide

Guidance literature:: C₂₀H₁₆ClN₅O₂S₂; acetic anhydride; With triethylamine; In dichloromethane; for 0.5h;

With potassium carbonate; In methanol; at 20 ℃; for 0.5h;
DOI:10.1021/jm301572h

Reference yield:

: C₂₄H₂₀ClN₅O₄S₂

: 1240518-65-3
N-({3-[(3-{[(5-chloro-2-thienyl)sulfonyl]amino}-4-cyano-1H-indazol-1-yl)methyl]phenyl}methyl)acetamide

Guidance literature:: With potassium carbonate; In methanol; at 20 ℃; for 0.5h;

Reference yield:

: 1240518-64-2
1,1-dimethylethyl ({3-[(3-{[(5-chloro-2-thienyl)sulfonyl]amino}-4-cyano-1H-indazol-1-yl)methyl]phenyl}methyl)carbamate

: 108-24-7
acetic anhydride

: 1240518-65-3
N-({3-[(3-{[(5-chloro-2-thienyl)sulfonyl]amino}-4-cyano-1H-indazol-1-yl)methyl]phenyl}methyl)acetamide

: C₂₄H₂₀ClN₅O₄S₂

Guidance literature:: 1,1-dimethylethyl ({3-[(3-{[(5-chloro-2-thienyl)sulfonyl]amino}-4-cyano-1H-indazol-1-yl)methyl]phenyl}methyl)carbamate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.5h;

acetic anhydride; With triethylamine; In dichloromethane; for 0.5h;