5-(2-methylphenyl)-3-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyridine-2-carboxamide

Base Information

Chemical Name:5-(2-methylphenyl)-3-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyridine-2-carboxamide
CAS No.:1389440-61-2
Molecular Formula:C₂₄H₂₇N₅O
Molecular Weight:401.511
Hs Code.:

Synonyms:5-(2-methylphenyl)-3-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyridine-2-carboxamide

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Chemical Property of 5-(2-methylphenyl)-3-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyridine-2-carboxamide

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Technology Process of 5-(2-methylphenyl)-3-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyridine-2-carboxamide

There total 4 articles about 5-(2-methylphenyl)-3-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyridine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1389440-63-4
5-bromo-3-(4-(4-methylpiperazin-1-yl)phenylamino)picolinamide

: 16419-60-6
2-Methylphenylboronic acid

: 1389440-61-2
5-(2-methylphenyl)-3-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyridine-2-carboxamide

Guidance literature:: With caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; at 150 ℃; for 0.5h; Microwave irradiation;

Reference yield:

: 573675-25-9
5-bromo-3-nitropyridine-2-carbonitrile

: 1389440-61-2
5-(2-methylphenyl)-3-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyridine-2-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / -25 - 20 °C

2: triethylamine / isopropyl alcohol / Microwave irradiation

3: tert-butyl alcohol; sodium t-butanolate / 2 h / 90 °C

4: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 0.5 h / 150 °C / Microwave irradiation

With tetrabutyl ammonium fluoride; caesium carbonate; triethylamine; sodium t-butanolate; tert-butyl alcohol; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; isopropyl alcohol; 4: Suzuki Coupling;

Reference yield:

: 886373-28-0
5-bromo-3-fluoropyridine-2-carbonitrile

: 1389440-61-2
5-(2-methylphenyl)-3-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyridine-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / isopropyl alcohol / Microwave irradiation

2: tert-butyl alcohol; sodium t-butanolate / 2 h / 90 °C

3: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 0.5 h / 150 °C / Microwave irradiation

With caesium carbonate; triethylamine; sodium t-butanolate; tert-butyl alcohol; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; isopropyl alcohol; 3: Suzuki Coupling;