N₁-methyl-N₃-phenyl-N₃-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)propane-1,3-diamine

Base Information

Chemical Name:N₁-methyl-N₃-phenyl-N₃-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)propane-1,3-diamine
CAS No.:1254704-87-4
Molecular Formula:C₂₂H₃₁N₃O
Molecular Weight:353.508
Hs Code.:

N<sub>1</sub>-methyl-N<sub>3</sub>-phenyl-N<sub>3</sub>-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)propane-1,3-diamine

Synonyms:N₁-methyl-N₃-phenyl-N₃-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)propane-1,3-diamine

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Chemical Property of N₁-methyl-N₃-phenyl-N₃-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)propane-1,3-diamine

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Technology Process of N₁-methyl-N₃-phenyl-N₃-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)propane-1,3-diamine

There total 3 articles about N₁-methyl-N₃-phenyl-N₃-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)propane-1,3-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 5814-44-8
N-3-chloropropyl-N-methylbenzenemethanamine hydrochloride

: 60709-31-1
N-phenyl-4-(2-(pyrrolidin-1-yl)ethoxy)aniline

: 1254704-87-4
N₁-methyl-N₃-phenyl-N₃-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)propane-1,3-diamine

Guidance literature:: N-phenyl-4-(2-(pyrrolidin-1-yl)ethoxy)aniline; With sodium hydride; In N,N-dimethyl-formamide; for 0.166667h; Inert atmosphere;

N-3-chloropropyl-N-methylbenzenemethanamine hydrochloride; With sodium hydride; In N,N-dimethyl-formamide; at 20 - 70 ℃; for 1.08333h;

With 10 wt% Pd(OH)2 on carbon; hydrogen; In isopropyl alcohol; at 80 ℃; for 4h;

Reference yield:

: 1254705-01-5
N₁-benzyl-N₁-methyl-N₃-phenyl-N₃-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)propane-1,3-diamine

: 1254704-87-4
N₁-methyl-N₃-phenyl-N₃-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)propane-1,3-diamine

Guidance literature:: With 20% palladium hydroxide on carbon; hydrogen; In isopropyl alcohol; at 80 ℃; for 4h;
DOI:10.1021/jm100666w

Reference yield:

: 122-37-2
4-anilinophenol

: 1254704-87-4
N₁-methyl-N₃-phenyl-N₃-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)propane-1,3-diamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h

1.2: 20 - 70 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / Inert atmosphere

2.2: 1.08 h / 20 - 70 °C

2.3: 4 h / 80 °C

With sodium hydride; In N,N-dimethyl-formamide;