Technology Process of C12H11ClN2O2*ClH
There total 5 articles about C12H11ClN2O2*ClH which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
oxalyl dichloride; N,N-dimethyl-formamide;
In
dichloromethane;
for 1h;
Reflux;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium carbonate / dimethyl sulfoxide / 16 h / 125 °C / Autoclave; Inert atmosphere
2.1: hydrogen; thiophene / palladium 10% on activated carbon / methanol / 3 h / 50 °C
3.1: sodium nitrite; sulfuric acid / acetic acid / 0.5 h / 10 - 20 °C
3.2: 1 h / 20 °C
3.3: Alkaline conditions
4.1: 1,3-bis-(diphenylphosphino)propane; palladium diacetate / tetrahydrofuran / 24 h / 150 °C / 15001.5 Torr / Autoclave; Inert atmosphere
4.2: Acidic aqueous solution
5.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 1 h / Reflux
With
thiophene; oxalyl dichloride; sulfuric acid; hydrogen; potassium carbonate; N,N-dimethyl-formamide; sodium nitrite;
palladium 10% on activated carbon; 1,3-bis-(diphenylphosphino)propane; palladium diacetate;
In
tetrahydrofuran; methanol; dichloromethane; acetic acid; dimethyl sulfoxide;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 1,3-bis-(diphenylphosphino)propane; palladium diacetate / tetrahydrofuran / 24 h / 150 °C / 15001.5 Torr / Autoclave; Inert atmosphere
1.2: Acidic aqueous solution
2.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 1 h / Reflux
With
oxalyl dichloride; N,N-dimethyl-formamide;
1,3-bis-(diphenylphosphino)propane; palladium diacetate;
In
tetrahydrofuran; dichloromethane;
