2'-DEOXYCYTIDYLYL(3'5')-THYMIDINEAMMONIU M

Base Information

• Chemical Name: 2'-DEOXYCYTIDYLYL(3'5')-THYMIDINEAMMONIU M
• CAS No.: 77710-60-2
• Molecular Formula: C₁₉H₂₆N₅O₁₁P*H₃N
• Molecular Weight: 548.447
• Mol file: 77710-60-2.mol

Synonyms:2’-DEOXYCYTIDYLYL(3’5’)-THYMIDINEAMMONIU M;2’-deoxycytidyl(3’->5’)-thymidine ammonium salt;2μ-Deoxycytidylyl(3μ-5μ)-thymidine ammonium salt

Chemical Property of 2'-DEOXYCYTIDYLYL(3'5')-THYMIDINEAMMONIU M

Chemical Property:

• Storage Temp.: −20°C

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2'-DEOXYCYTIDYLYL(3'5')-THYMIDINEAMMONIU M

There total 9 articles about 2'-DEOXYCYTIDYLYL(3'5')-THYMIDINEAMMONIU M which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

C27H32N5O11PS → 2'-deoxycytosylyl-(3',5')-thymidine ammonium salt (77710-60-2) + Thiophosphoric acid O-[(2R,3S,5R)-5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-2-hydroxymethyl-tetrahydro-furan-3-yl] ester O'-[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester S-methyl ester

Guidance literature:

With ammonium hydroxide; for 2h; Ambient temperature;

Reference yield:

2'-deoxycytidine monohydrochloride (3992-42-5) → 2'-deoxycytosylyl-(3',5')-thymidine ammonium salt (77710-60-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 70 percent / dichloroacetic acid, Et₃N, pyridine / 1.5 h / 25 °C

2: ethyldiisopropylamine / tetrahydrofuran / 1 h / 25 °C

With pyridine; dichloro-acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;

DOI:10.1021/ja973731g

Reference yield:

5'-O-(4,4'-dimethoxytrityl)deoxycytidine (76512-82-8) → 2'-deoxycytosylyl-(3',5')-thymidine ammonium salt (77710-60-2)

Guidance literature:

Multi-step reaction with 2 steps

1: ethyldiisopropylamine / tetrahydrofuran / 1 h / 25 °C

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;

DOI:10.1021/ja973731g

upstream raw materials:

C₃₇H₄₃N₆O₁₆P

5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine-3'-O-[(2-cyanoethyl)-N,N-diisopropylphosphoramidite]

2'-deoxycytidine monohydrochloride

5'-O-(4,4'-dimethoxytrityl)deoxycytidine