(S)-2-(5-(cyclopropylethynyl)-4-phenyl-1H-1,2,3-triazol-1-yl)-N-hydroxy-3-phenylpropanamide

Base Information

Chemical Name:(S)-2-(5-(cyclopropylethynyl)-4-phenyl-1H-1,2,3-triazol-1-yl)-N-hydroxy-3-phenylpropanamide
CAS No.:1620779-53-4
Molecular Formula:C₂₂H₂₀N₄O₂
Molecular Weight:372.426
Hs Code.:

Synonyms:(S)-2-(5-(cyclopropylethynyl)-4-phenyl-1H-1,2,3-triazol-1-yl)-N-hydroxy-3-phenylpropanamide

Suppliers and Price of (S)-2-(5-(cyclopropylethynyl)-4-phenyl-1H-1,2,3-triazol-1-yl)-N-hydroxy-3-phenylpropanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-(5-(cyclopropylethynyl)-4-phenyl-1H-1,2,3-triazol-1-yl)-N-hydroxy-3-phenylpropanamide

Chemical Property:

Purity/Quality:

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Technology Process of (S)-2-(5-(cyclopropylethynyl)-4-phenyl-1H-1,2,3-triazol-1-yl)-N-hydroxy-3-phenylpropanamide

There total 6 articles about (S)-2-(5-(cyclopropylethynyl)-4-phenyl-1H-1,2,3-triazol-1-yl)-N-hydroxy-3-phenylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1620779-55-6
(S)-methyl 2-(5-(cyclopropylethynyl)-4-phenyl-1H-1,2,3-triazol-1-yl)-3-phenylpropanoate

: 1620779-53-4
(S)-2-(5-(cyclopropylethynyl)-4-phenyl-1H-1,2,3-triazol-1-yl)-N-hydroxy-3-phenylpropanamide

Guidance literature:: With sodium cyanide; hydroxylamine; In tetrahydrofuran; methanol; water; at 20 ℃; for 16h;
DOI:10.1021/acsmedchemlett.6b00239

Reference yield:

: 932-88-7
1-iodo-2-phenylethyne

: 1620779-53-4
(S)-2-(5-(cyclopropylethynyl)-4-phenyl-1H-1,2,3-triazol-1-yl)-N-hydroxy-3-phenylpropanamide

Guidance literature:: Multi-step reaction with 3 steps

1: copper(l) iodide; triethylamine / tetrahydrofuran

2: triethylamine; bis-triphenylphosphine-palladium(II) chloride / toluene / 110 °C

3: hydroxylamine; sodium cyanide / methanol; tetrahydrofuran; water

With sodium cyanide; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; hydroxylamine; triethylamine; In tetrahydrofuran; methanol; water; toluene;

Reference yield:

: 116911-32-1
(S)-2-azido-3-phenylpropionic acid methyl ester

: 1620779-53-4
(S)-2-(5-(cyclopropylethynyl)-4-phenyl-1H-1,2,3-triazol-1-yl)-N-hydroxy-3-phenylpropanamide

Guidance literature:: Multi-step reaction with 3 steps

1: copper(l) iodide; triethylamine / tetrahydrofuran

2: triethylamine; bis-triphenylphosphine-palladium(II) chloride / toluene / 110 °C

3: hydroxylamine; sodium cyanide / methanol; tetrahydrofuran; water

With sodium cyanide; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; hydroxylamine; triethylamine; In tetrahydrofuran; methanol; water; toluene;