5-{2-[2-(2-chloro-4-fluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}nicotinic acid

Base Information

Chemical Name:5-{2-[2-(2-chloro-4-fluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}nicotinic acid
CAS No.:632622-80-1
Molecular Formula:C₂₄H₁₈ClFN₂O₃
Molecular Weight:436.87
Hs Code.:

Synonyms:5-{2-[2-(2-chloro-4-fluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}nicotinic acid

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Chemical Property of 5-{2-[2-(2-chloro-4-fluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}nicotinic acid

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Technology Process of 5-{2-[2-(2-chloro-4-fluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}nicotinic acid

There total 9 articles about 5-{2-[2-(2-chloro-4-fluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}nicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 5-{2-[2-(2-chloro-4-fluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}nicotinic acid ethyl ester

: 632622-80-1
5-{2-[2-(2-chloro-4-fluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}nicotinic acid

Guidance literature:: With sodium hydroxide; water; In ethanol; at 100 ℃; for 1h;

Reference yield:

: 20826-04-4
5-bromo-3-pyridinecarboxylic acid

: 632622-80-1
5-{2-[2-(2-chloro-4-fluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}nicotinic acid

Guidance literature:: Multi-step reaction with 6 steps

1: ammonia / copper(II) sulfate / water / 15 h / 180 °C

2: hydrogenchloride / 1,4-dioxane / 16 h / Heating / reflux

3: toluene / 72 h / 150 °C

4: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

5: potassium carbonate / DMF (N,N-dimethyl-formamide) / 3 h / 65 °C

6: sodium hydroxide; water / ethanol / 1 h / 100 °C

With hydrogenchloride; sodium hydroxide; ammonia; water; potassium carbonate; copper(II) sulfate; In 1,4-dioxane; DMF (N,N-dimethyl-formamide); ethanol; water; toluene;

Reference yield:

: 17285-76-6
5-aminonicotinic acid ethyl ester

: 632622-80-1
5-{2-[2-(2-chloro-4-fluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}nicotinic acid

Guidance literature:: Multi-step reaction with 4 steps

1: toluene / 72 h / 150 °C

2: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

3: potassium carbonate / DMF (N,N-dimethyl-formamide) / 3 h / 65 °C

4: sodium hydroxide; water / ethanol / 1 h / 100 °C

With hydrogenchloride; sodium hydroxide; water; potassium carbonate; In 1,4-dioxane; DMF (N,N-dimethyl-formamide); ethanol; toluene;