7-methoxy-14-oxo-16-(2-phenoxyethyl)-3,13-diaza-16-azoniapentacyclo[14.2.1.0-1,13-.0-2,10-.0-4,9-]nonadeca-2⁽¹⁰⁾,4,6,8-tetraene chloride

Base Information

• Chemical Name: 7-methoxy-14-oxo-16-(2-phenoxyethyl)-3,13-diaza-16-azoniapentacyclo[14.2.1.0-1,13-.0-2,10-.0-4,9-]nonadeca-2⁽¹⁰⁾,4,6,8-tetraene chloride
• CAS No.: 853019-58-6
• Molecular Formula: C₂₅H₂₈N₃O₃*Cl
• Molecular Weight: 453.969

Synonyms:7-methoxy-14-oxo-16-(2-phenoxyethyl)-3,13-diaza-16-azoniapentacyclo[14.2.1.0-1,13-.0-2,10-.0-4,9-]nonadeca-2⁽¹⁰⁾,4,6,8-tetraene chloride

Chemical Property of 7-methoxy-14-oxo-16-(2-phenoxyethyl)-3,13-diaza-16-azoniapentacyclo[14.2.1.0-1,13-.0-2,10-.0-4,9-]nonadeca-2⁽¹⁰⁾,4,6,8-tetraene chloride

Chemical Property:

Purity/Quality:

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Technology Process of 7-methoxy-14-oxo-16-(2-phenoxyethyl)-3,13-diaza-16-azoniapentacyclo[14.2.1.0-1,13-.0-2,10-.0-4,9-]nonadeca-2⁽¹⁰⁾,4,6,8-tetraene chloride

There total 9 articles about 7-methoxy-14-oxo-16-(2-phenoxyethyl)-3,13-diaza-16-azoniapentacyclo[14.2.1.0-1,13-.0-2,10-.0-4,9-]nonadeca-2⁽¹⁰⁾,4,6,8-tetraene chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

methanol (67-56-1) + 2-(chloroacetyl)-6-methoxy-1'-(2-phenoxyethyl)-2,3,4,9-tetrahydrospiro[β-carboline-1,3'-pyrrolidine] (853020-82-3) → 7-methoxy-14-oxo-16-(2-phenoxyethyl)-3,13-diaza-16-azoniapentacyclo[14.2.1.0-1,13-.0-2,10-.0-4,9-]nonadeca-2(10),4,6,8-tetraene chloride (853019-58-6)

Guidance literature:

Reference yield:

5-methoxytryptamine hydrochloride (66-83-1) → 7-methoxy-14-oxo-16-(2-phenoxyethyl)-3,13-diaza-16-azoniapentacyclo[14.2.1.0-1,13-.0-2,10-.0-4,9-]nonadeca-2(10),4,6,8-tetraene chloride (853019-58-6)

Guidance literature:

Multi-step reaction with 5 steps

1.1: acetic acid / 1 h / 100 °C

1.2: 72 h

2.1: chiral preparative HPLC_.; Resolution of racemate

3.1: potassium carbonate / acetonitrile / 12 h / 70 °C

4.1: potassium carbonate / acetonitrile / 0.17 h / 20 °C

With potassium carbonate; acetic acid; In acetonitrile;

Reference yield:

1'-benzyl-6-methoxy-2,3,4,9-tetrahydrospiro[β-carboline-1,3'-pyrrolidine] (853020-88-9,853020-89-0,853020-91-4) → 7-methoxy-14-oxo-16-(2-phenoxyethyl)-3,13-diaza-16-azoniapentacyclo[14.2.1.0-1,13-.0-2,10-.0-4,9-]nonadeca-2(10),4,6,8-tetraene chloride (853019-58-6)

Guidance literature:

Multi-step reaction with 5 steps

1: hydrogen / palladium dihydroxide / methanol; water / 58 °C

2: chiral preparative HPLC_.; Resolution of racemate

3: potassium carbonate / acetonitrile / 12 h / 70 °C

4: potassium carbonate / acetonitrile / 0.17 h / 20 °C

With hydrogen; potassium carbonate; palladium dihydroxide; In methanol; water; acetonitrile;

upstream raw materials:

methanol

2-(chloroacetyl)-6-methoxy-1'-(2-phenoxyethyl)-2,3,4,9-tetrahydrospiro[β-carboline-1,3'-pyrrolidine]

1'-benzyl-6-methoxy-2,3,4,9-tetrahydrospiro[β-carboline-1,3'-pyrrolidine]

5-methoxytryptamine hydrochloride

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