(S)-3-amino-5-(2,4-dichloro-6-ethoxyphenyl)-1H-benzo[e][1,4]diazepin-2(3H)-one

Base Information

Chemical Name:(S)-3-amino-5-(2,4-dichloro-6-ethoxyphenyl)-1H-benzo[e][1,4]diazepin-2(3H)-one
CAS No.:1351281-48-5
Molecular Formula:C₁₇H₁₅Cl₂N₃O₂
Molecular Weight:364.231
Hs Code.:

Synonyms:(S)-3-amino-5-(2,4-dichloro-6-ethoxyphenyl)-1H-benzo[e][1,4]diazepin-2(3H)-one

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Chemical Property of (S)-3-amino-5-(2,4-dichloro-6-ethoxyphenyl)-1H-benzo[e][1,4]diazepin-2(3H)-one

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Technology Process of (S)-3-amino-5-(2,4-dichloro-6-ethoxyphenyl)-1H-benzo[e][1,4]diazepin-2(3H)-one

There total 13 articles about (S)-3-amino-5-(2,4-dichloro-6-ethoxyphenyl)-1H-benzo[e][1,4]diazepin-2(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1351281-46-3
(S)-3-amino-5-(2,4-dichloro-6-ethoxyphenyl)-1-(4-methoxybenzyl)-1H-benzo[e][1,4]diazepin-2(3H)-one

: 1351281-48-5
(S)-3-amino-5-(2,4-dichloro-6-ethoxyphenyl)-1H-benzo[e][1,4]diazepin-2(3H)-one

Guidance literature:: With ammonium cerium (IV) nitrate; In water; acetonitrile; at 0 ℃; for 5h;

Reference yield:

: 376584-35-9
3-azido-5-chloro-1-(4-methoxy-benzyl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one

: 1351281-48-5
(S)-3-amino-5-(2,4-dichloro-6-ethoxyphenyl)-1H-benzo[e][1,4]diazepin-2(3H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogen / platinum(IV) oxide / 1,4-dioxane / 3 h / 7500.75 Torr / Autoclave

2: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 3.75 h / 80 °C / Inert atmosphere

3: hydrogenchloride / 1,4-dioxane / 12 h / 18 - 23 °C / Inert atmosphere

4: sodium hydrogencarbonate; 3,5-dichlorosalicyclaldehyde; (2R,3R)-2,3-bis(benzyloxy)tartaric acid / dichloromethane; water; Isopropyl acetate / 3 h / 70 °C

5: ammonium cerium (IV) nitrate / acetonitrile; water / 5 h / 0 °C

With hydrogenchloride; ammonium cerium (IV) nitrate; (2R,3R)-2,3-bis(benzyloxy)tartaric acid; hydrogen; sodium hydrogencarbonate; sodium carbonate; 3,5-dichlorosalicyclaldehyde; platinum(IV) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; Isopropyl acetate; water; acetonitrile;

Reference yield:

: 376584-36-0
[5-chloro-1-(4-methoxy-benzyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-carbamic acid tert-butyl ester

: 1351281-48-5
(S)-3-amino-5-(2,4-dichloro-6-ethoxyphenyl)-1H-benzo[e][1,4]diazepin-2(3H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 3.75 h / 80 °C / Inert atmosphere

2: hydrogenchloride / 1,4-dioxane / 12 h / 18 - 23 °C / Inert atmosphere

3: sodium hydrogencarbonate; 3,5-dichlorosalicyclaldehyde; (2R,3R)-2,3-bis(benzyloxy)tartaric acid / dichloromethane; water; Isopropyl acetate / 3 h / 70 °C

4: ammonium cerium (IV) nitrate / acetonitrile; water / 5 h / 0 °C

With hydrogenchloride; ammonium cerium (IV) nitrate; (2R,3R)-2,3-bis(benzyloxy)tartaric acid; sodium hydrogencarbonate; sodium carbonate; 3,5-dichlorosalicyclaldehyde; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; Isopropyl acetate; water; acetonitrile;