376584-35-9

Upstream product

• 376584-34-8 2H-1,4-benzodiazepin-2-one, 5-chloro-1,3-dihydro-1-(4-methoxybenzyl)- 
• 5118-94-5 1,4-benzodiazepine-2,5-dione 
• 5363-29-1 2-(4-methoxybenzylamino)benzoic acid 
• 123-11-5 4-methoxy-benzaldehyde 
• 16512-74-6 1-(4-methoxybenzyl)-2H-benzo[d][1,3]oxazine-2,4(1H)-dione 
• 118-92-3 anthranilic acid 
• 169504-53-4 1-(4-ethoxy-benzyl)-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione 
• 824-94-2 p-methoxybenzyl chloride 

Downstream Products

• 376584-36-0 [5-chloro-1-(4-methoxy-benzyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-carbamic acid tert-butyl ester 
• 1271523-96-6 5-chloro-2-(3-methoxypropoxy)-N-(2-oxo-5-(2,4,6-trichlorophenyl)-2,3-dihydro-1H-benzo[e] [1,4]diazepin-3-yl)benzamide 
• 1271523-97-7 5-chloro-2-((S)-2-methoxypropoxy)-N-(2-oxo-5-(2,4,6-trichlorophenyl)-2,3-dihydro-1H-benzo[e] [1,4]diazepin-3-yl)benzamide 
• 1271524-43-6 5-chloro-N-(5-(2,6-dichlorophenyl)-2-oxo-2,3-dihydro-1H-benzo[e] [1,4]diazepin-3-yl)-2-(2-methoxyethoxy)benzamide 
• 1271524-44-7 N-(5-(2,6-dichlorophenyl)-2-oxo-2,3-dihydro-1H-benzo[e] [1,4]diazepin-3-yl)-5-fluoro-2-(2-methoxyethoxy)benzamide 
• 1271523-25-1 tert-butyl 5-(2,6-dichlorophenyl)-1-(4-methoxybenzyl)-2-oxo-2,3-dihydro-1H-benzo[e] [1,4]diazepin-3-ylcarbamate 
• 1271523-27-3 [1-(4-methoxy-benzyl)-2-oxo-5-(2,4,6-trichloro-phenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-carbamic acid tert-butyl ester 
• 1271523-29-5 3-amino-5-(2,6-dichlorophenyl)-1-(4-methoxybenzyl)-1H-benzo[e] [1,4]diazepin-2(3H)-one 
• 1271523-31-9 3-amino-1-(4-methoxybenzyl)-5-(2,4,6-trichlorophenyl)-1,3-dihydrobenzo[e] [1,4]diazepin-2-one 
• 1271523-33-1 3-amino-5-(2,4,6-trichlorophenyl)-1,3-dihydrobenzo[e] [1,4] diazepin-2-one hydrochloride 
• 1271523-40-0 tert-butyl 5-(2,4-dichloro-6-(morpholinomethyl)phenyl)-1-(4-methoxybenzyl)-2-oxo-2,3-dihydro-1H-benzo[e] [1,4]diazepin-3-ylcarbamate 
• 1271523-41-1 tert-butyl 5-(2,4-dichloro-6-methoxyphenyl)-1-(4-methoxybenzyl)-2-oxo-2,3-dihydro-1H-benzo[e] [1,4]diazepin-3-ylcarbamate 
• 1271523-42-2 tert-butyl 5-(2,4-dichloro-6-ethoxyphenyl)-1-(4-methoxybenzyl)-2-oxo-2,3-dihydro-1H-benzo[e] [1,4]diazepin-3-ylcarbamate 
• 1271523-43-3 3-amino-5-(2,4-dichloro-6-(morpholinomethyl)phenyl)-1H-benzo[e] [1,4]diazepin-2(3H)-one 

Relevant academic research and scientific papers

BENZODIAZEPINE DERIVATIVES FOR TREATING HEPATITIS C INFECTION

The invention concerns benzodiazepine derivatives of Formula (I) wherein W, X, L1, L2, L3, R1, R2, R3, R4, R5, R6 and R7 are as defined in the description. The present invention also relates to processes for the preparation of such compounds, pharmaceutical compositions containing them and their use in the treatment or prophylaxis of hepatitis C virus infection.

BENZODIAZEPINE COMPOUNDS USEFUL FOR THE TREATMENT OF HEPATITIS C

The invention concerns benzodiazepine derivatives of Formula (I): wherein X, L1, L2, R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as defined in the description. The present invention also relates to processes for the preparation of such compounds, pharmaceutical compositions containing them and their use in the treatment or prophylaxis of hepatitis C virus infection.

BENZODIAZEPINE COMPOUNDS USEFUL FOR THE TREATMENT OF HEPATITIS C

The invention concerns benzodiazepine derivatives of Formula (I) wherein A, X, L1, L2, R1, R2, R3, R4, R5, R6 and R7 are as defined in the description. The present invention also relates to processes for the preparation of such compounds, pharmaceutical compositions containing them and their use in the treatment or prophylaxis of hepatitis C virus infection.

New synthesis of 1,3-dihydro-1,4-benzodiazepin-2(2H)-ones and 3-amino-1,3-dihydro-1,4-benzodiazepin-2(2H)-ones: Pd-catalyzed cross-coupling of imidoyl chlorides with organoboronic acids

A new approach to the synthesis of 1,4-benzodiazepines and 3-amino-1,4-benzodiazepines, which employs the Pd-catalyzed cross-coupling reaction of an imidoyl chloride with an organometallic reagent as the key step, is described. A five-step synthesis of a