4-[[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methylcarbamoyl]amino]-2-fluoro-N,N-dimethylbenzamide

Base Information

Chemical Name:4-[[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methylcarbamoyl]amino]-2-fluoro-N,N-dimethylbenzamide
CAS No.:1402582-03-9
Molecular Formula:C₂₁H₁₈ClF₄N₅O₂
Molecular Weight:483.853
Hs Code.:

Synonyms:4-[[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methylcarbamoyl]amino]-2-fluoro-N,N-dimethylbenzamide

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Chemical Property of 4-[[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methylcarbamoyl]amino]-2-fluoro-N,N-dimethylbenzamide

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Technology Process of 4-[[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methylcarbamoyl]amino]-2-fluoro-N,N-dimethylbenzamide

There total 5 articles about 4-[[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methylcarbamoyl]amino]-2-fluoro-N,N-dimethylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1402582-08-4
4-(3-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)ureido)-2-fluorobenzoic acid

: 124-40-3
dimethyl amine

: 1402582-03-9
4-[[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methylcarbamoyl]amino]-2-fluoro-N,N-dimethylbenzamide

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; at 23 ℃; for 2h;

Reference yield:

: 73792-08-2
methyl 4-amino-2-fluorobenzoate

: 1402582-03-9
4-[[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methylcarbamoyl]amino]-2-fluoro-N,N-dimethylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: dmap / acetonitrile / Reflux

2: lithium hydroxide monohydrate / water; tetrahydrofuran / 2 h / 40 °C

3: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide; tetrahydrofuran / 2 h / 23 °C

With dmap; lithium hydroxide monohydrate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 392-09-6
2-fluoro-4-nitro-benzoic acid methyl ester

: 1402582-03-9
4-[[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methylcarbamoyl]amino]-2-fluoro-N,N-dimethylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: palladium on activated charcoal; hydrogen / methanol / 2 h / 23 °C

2: dmap / acetonitrile / Reflux

3: lithium hydroxide monohydrate / water; tetrahydrofuran / 2 h / 40 °C

4: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide; tetrahydrofuran / 2 h / 23 °C

With dmap; lithium hydroxide monohydrate; palladium on activated charcoal; hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetonitrile;