2-(2,6-Difluoro-phenyl)-5-(5-methyl-2-pyridin-2-yl-thiazol-4-yl)-1H-indole

Base Information

Chemical Name:2-(2,6-Difluoro-phenyl)-5-(5-methyl-2-pyridin-2-yl-thiazol-4-yl)-1H-indole
CAS No.:1279103-44-4
Molecular Formula:C₂₃H₁₅F₂N₃S
Molecular Weight:403.455
Hs Code.:

Synonyms:2-(2,6-Difluoro-phenyl)-5-(5-methyl-2-pyridin-2-yl-thiazol-4-yl)-1H-indole

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Chemical Property of 2-(2,6-Difluoro-phenyl)-5-(5-methyl-2-pyridin-2-yl-thiazol-4-yl)-1H-indole

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Technology Process of 2-(2,6-Difluoro-phenyl)-5-(5-methyl-2-pyridin-2-yl-thiazol-4-yl)-1H-indole

There total 7 articles about 2-(2,6-Difluoro-phenyl)-5-(5-methyl-2-pyridin-2-yl-thiazol-4-yl)-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.0%

: 1279106-31-8
(E)-N-[1-(2,6-difluorophenyl)ethylidene]-N'-[1-(5-methyl-2-pyridin-2-ylthiazol-4-yl)phenyl]hydrazine

: 1279103-44-4
2-(2,6-Difluoro-phenyl)-5-(5-methyl-2-pyridin-2-yl-thiazol-4-yl)-1H-indole

Guidance literature:: With polyphosphoric acid; at 130 ℃; for 2h;

Reference yield:

: 3758-70-1
1-(4-nitrophenyl)propan-1-one

: 1279103-44-4
2-(2,6-Difluoro-phenyl)-5-(5-methyl-2-pyridin-2-yl-thiazol-4-yl)-1H-indole

Guidance literature:: Multi-step reaction with 6 steps

1.1: bromine / tetrachloromethane / 1 h / 20 °C

2.1: ethanol / 2 h / Reflux

3.1: hydrogen / palladium on activated charcoal / ethyl acetate / 18 h

4.1: hydrogenchloride; sodium nitrite / water / 3 h / 0 °C

4.2: 48 h / 20 °C

5.1: sodium acetate / ethanol; water / 48 h

6.1: polyphosphoric acid / 2 h / 130 °C

With hydrogenchloride; hydrogen; bromine; sodium acetate; sodium nitrite; palladium on activated charcoal; In tetrachloromethane; ethanol; water; ethyl acetate;

Reference yield:

: 1205-56-7
2-bromo-1-(4-nitrophenyl)propan-1-one

: 1279103-44-4
2-(2,6-Difluoro-phenyl)-5-(5-methyl-2-pyridin-2-yl-thiazol-4-yl)-1H-indole

Guidance literature:: Multi-step reaction with 5 steps

1.1: ethanol / 2 h / Reflux

2.1: hydrogen / palladium on activated charcoal / ethyl acetate / 18 h

3.1: hydrogenchloride; sodium nitrite / water / 3 h / 0 °C

3.2: 48 h / 20 °C

4.1: sodium acetate / ethanol; water / 48 h

5.1: polyphosphoric acid / 2 h / 130 °C

With hydrogenchloride; hydrogen; sodium acetate; sodium nitrite; palladium on activated charcoal; In ethanol; water; ethyl acetate;