2,2,2-trichloroethyl [(1-benzyl-1H-tetrazol-5-yl){4-[2-(3-methyl-3H-diaziren-3-yl)ethoxy]phenyl}methyl]2-propyn-1-ylcarbamate

Base Information

Chemical Name:2,2,2-trichloroethyl [(1-benzyl-1H-tetrazol-5-yl){4-[2-(3-methyl-3H-diaziren-3-yl)ethoxy]phenyl}methyl]2-propyn-1-ylcarbamate
CAS No.:1620482-59-8
Molecular Formula:C₂₅H₂₄Cl₃N₇O₃
Molecular Weight:576.87
Hs Code.:

Synonyms:2,2,2-trichloroethyl [(1-benzyl-1H-tetrazol-5-yl){4-[2-(3-methyl-3H-diaziren-3-yl)ethoxy]phenyl}methyl]2-propyn-1-ylcarbamate

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Chemical Property of 2,2,2-trichloroethyl [(1-benzyl-1H-tetrazol-5-yl){4-[2-(3-methyl-3H-diaziren-3-yl)ethoxy]phenyl}methyl]2-propyn-1-ylcarbamate

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Technology Process of 2,2,2-trichloroethyl [(1-benzyl-1H-tetrazol-5-yl){4-[2-(3-methyl-3H-diaziren-3-yl)ethoxy]phenyl}methyl]2-propyn-1-ylcarbamate

There total 3 articles about 2,2,2-trichloroethyl [(1-benzyl-1H-tetrazol-5-yl){4-[2-(3-methyl-3H-diaziren-3-yl)ethoxy]phenyl}methyl]2-propyn-1-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1620482-54-3
N-[(1-benzyl-1H-tetrazol-5-yl){4-[2-(3-methyl-3H-diaziren-3-yl)ethoxy]phenyl}methyl]-2-propyn-1-amine

: 17341-93-4
2,2,2-Trichloroethyl chloroformate

: 1620482-59-8
2,2,2-trichloroethyl [(1-benzyl-1H-tetrazol-5-yl){4-[2-(3-methyl-3H-diaziren-3-yl)ethoxy]phenyl}methyl]2-propyn-1-ylcarbamate

Guidance literature:: With sodium hydrogencarbonate; In water; ethyl acetate; at 0 - 20 ℃; for 1h; Inert atmosphere;
DOI:10.1021/ja505517t

Reference yield:

: 1620483-11-5
{4-[2-(3-methyl-3H-diaziren-3-yl)ethoxy]phenyl}methanol

: 1620482-59-8
2,2,2-trichloroethyl [(1-benzyl-1H-tetrazol-5-yl){4-[2-(3-methyl-3H-diaziren-3-yl)ethoxy]phenyl}methyl]2-propyn-1-ylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: sulfur trioxide pyridine complex; triethylamine / ethyl acetate; dimethyl sulfoxide / 0.33 h / 0 - 20 °C / Inert atmosphere

2: trimethylsilylazide / methanol / 0 - 20 °C / Inert atmosphere

3: sodium hydrogencarbonate / ethyl acetate; water / 1 h / 0 - 20 °C / Inert atmosphere

With trimethylsilylazide; sulfur trioxide pyridine complex; sodium hydrogencarbonate; triethylamine; In methanol; water; dimethyl sulfoxide; ethyl acetate;
DOI:10.1021/ja505517t

Reference yield:

: 1620483-12-6
4-[2-(3-methyl-3H-diaziren-3-yl)ethoxy]benzaldehyde

: 1620482-59-8
2,2,2-trichloroethyl [(1-benzyl-1H-tetrazol-5-yl){4-[2-(3-methyl-3H-diaziren-3-yl)ethoxy]phenyl}methyl]2-propyn-1-ylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: trimethylsilylazide / methanol / 0 - 20 °C / Inert atmosphere

2: sodium hydrogencarbonate / ethyl acetate; water / 1 h / 0 - 20 °C / Inert atmosphere

With trimethylsilylazide; sodium hydrogencarbonate; In methanol; water; ethyl acetate;
DOI:10.1021/ja505517t