ethyl 5-carboxylic acid-2-phenylbenzoxazole

Base Information

• Chemical Name: ethyl 5-carboxylic acid-2-phenylbenzoxazole
• CAS No.: 1239752-32-9
• Molecular Formula: C₁₆H₁₃NO₃
• Molecular Weight: 267.284
• Mol file: 1239752-32-9.mol

Synonyms:ethyl 5-carboxylic acid-2-phenylbenzoxazole

Chemical Property of ethyl 5-carboxylic acid-2-phenylbenzoxazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 5-carboxylic acid-2-phenylbenzoxazole

There total 9 articles about ethyl 5-carboxylic acid-2-phenylbenzoxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

C16H13NO6 (1261438-97-4) → ethyl 5-carboxylic acid-2-phenylbenzoxazole (1239752-32-9)

Guidance literature:

With palladium 10% on activated carbon; ammonium formate; acetic acid; for 14h; Reflux;

Reference yield: 60.0%

benzoyl chloride (98-88-4) + ethyl 3-amino-4-hydroxybenzoate (13052-92-1) → ethyl 5-carboxylic acid-2-phenylbenzoxazole (1239752-32-9)

Guidance literature:

With trichlorophosphate; In 1,4-dioxane; at 20 - 90 ℃; for 15h; Inert atmosphere;

DOI:10.1002/bkcs.11465

Reference yield: 56.0%

Ethyl 4-hydroxybenzoate (120-47-8) + 3-phenyl-4,4-dimethyl-5-oxo-2-isoxazoline (51942-54-2) → ethyl 5-carboxylic acid-2-phenylbenzoxazole (1239752-32-9)

Guidance literature:

With N,N'-di-tert-butylethylenediamine; potassium tert-butylate; copper diacetate; In 1,2-dichloro-ethane; at 80 ℃; for 12h; Sealed tube;

DOI:10.1021/acs.orglett.1c04322

upstream raw materials:

C₁₆H₁₃NO₆

(E)-ethyl 3-(benzylideneamino)-4-hydroxybenzoate

benzaldehyde

ethyl 3-amino-4-hydroxybenzoate

Downstream raw materials:

5-hydroxymethyl-2-phenylbenzo[d]oxazole

Refernces

• 1、 Wang, Zheng-Hai,Wang, Dong-Hui. "Cu-Catalyzed Synthesis of Benzoxazole with Phenol and Cyclic Oxime". . p. 782 - 785. Retrieved 2022/01/20.
• 2、 Liu, Dongfang,Liu, Bin,Cheng, Jiang. "The palladium-catalyzed tandem decarboxylation, carbon-carbon triple bond oxidation and decarbonylative arylation of the benzoxazole C-H bond". . p. 9193 - 9196. Retrieved 2013/07/27.