tert-butyl (S)-1-((S)-1-cyclohexyl-2-oxo-2-((S)-1-phenethylazepan-3-ylamino)ethylamino)-1-oxopropan-2-yl(methyl)carbamate

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Chemical Name:tert-butyl (S)-1-((S)-1-cyclohexyl-2-oxo-2-((S)-1-phenethylazepan-3-ylamino)ethylamino)-1-oxopropan-2-yl(methyl)carbamate
CAS No.:1361323-06-9
Molecular Formula:C₃₁H₅₀N₄O₄
Molecular Weight:542.762
Hs Code.:

Synonyms:tert-butyl (S)-1-((S)-1-cyclohexyl-2-oxo-2-((S)-1-phenethylazepan-3-ylamino)ethylamino)-1-oxopropan-2-yl(methyl)carbamate

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Chemical Property of tert-butyl (S)-1-((S)-1-cyclohexyl-2-oxo-2-((S)-1-phenethylazepan-3-ylamino)ethylamino)-1-oxopropan-2-yl(methyl)carbamate

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Technology Process of tert-butyl (S)-1-((S)-1-cyclohexyl-2-oxo-2-((S)-1-phenethylazepan-3-ylamino)ethylamino)-1-oxopropan-2-yl(methyl)carbamate

There total 7 articles about tert-butyl (S)-1-((S)-1-cyclohexyl-2-oxo-2-((S)-1-phenethylazepan-3-ylamino)ethylamino)-1-oxopropan-2-yl(methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₃H₄₂N₄O₄

: 122-78-1
phenylacetaldehyde

: 1361323-06-9
tert-butyl (S)-1-((S)-1-cyclohexyl-2-oxo-2-((S)-1-phenethylazepan-3-ylamino)ethylamino)-1-oxopropan-2-yl(methyl)carbamate

Guidance literature:: With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃; for 4h;
DOI:10.1016/j.bmcl.2011.12.109

Reference yield:

: 1361378-83-7
(S)-2-amino-N-((S)-1-benzylazepan-3-yl)-2-cyclohexylacetamide dihydrochloride

: 1361323-06-9
tert-butyl (S)-1-((S)-1-cyclohexyl-2-oxo-2-((S)-1-phenethylazepan-3-ylamino)ethylamino)-1-oxopropan-2-yl(methyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0 °C

1.2: 0 - 20 °C

2.1: palladium 10% on activated carbon; formic acid / methanol / 1 h / 20 °C

2.2: 5 h / 20 °C / 760.05 Torr

3.1: sodium tris(acetoxy)borohydride / dichloromethane / 4 h / 20 °C

With 4-methyl-morpholine; formic acid; palladium 10% on activated carbon; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.12.109

Reference yield:

: 635754-98-2
(S)-3-amino-1-benzylazepan-2-one hydrochloride

: 1361323-06-9
tert-butyl (S)-1-((S)-1-cyclohexyl-2-oxo-2-((S)-1-phenethylazepan-3-ylamino)ethylamino)-1-oxopropan-2-yl(methyl)carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: borane-THF / tetrahydrofuran / 20 °C / Inert atmosphere

2.1: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.17 h / 0 °C

2.2: 0 - 20 °C

3.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

4.1: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0 °C

4.2: 0 - 20 °C

5.1: palladium 10% on activated carbon; formic acid / methanol / 1 h / 20 °C

5.2: 5 h / 20 °C / 760.05 Torr

6.1: sodium tris(acetoxy)borohydride / dichloromethane / 4 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; formic acid; borane-THF; palladium 10% on activated carbon; sodium tris(acetoxy)borohydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.12.109