(S)-2-amino-N-((S)-1-benzylazepan-3-yl)-2-cyclohexylacetamide dihydrochloride

Base Information

Chemical Name:(S)-2-amino-N-((S)-1-benzylazepan-3-yl)-2-cyclohexylacetamide dihydrochloride
CAS No.:1361378-83-7
Molecular Formula:C₂₁H₃₃N₃O
Molecular Weight:343.513
Hs Code.:

Synonyms:(S)-2-amino-N-((S)-1-benzylazepan-3-yl)-2-cyclohexylacetamide dihydrochloride

Suppliers and Price of (S)-2-amino-N-((S)-1-benzylazepan-3-yl)-2-cyclohexylacetamide dihydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-2-amino-N-((S)-1-benzylazepan-3-yl)-2-cyclohexylacetamide dihydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-2-amino-N-((S)-1-benzylazepan-3-yl)-2-cyclohexylacetamide dihydrochloride

There total 5 articles about (S)-2-amino-N-((S)-1-benzylazepan-3-yl)-2-cyclohexylacetamide dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1361323-03-6
tert-butyl (S)-2-((S)-1-benzylazepan-3-ylamino)-1-cyclohexyl-2-oxoethylcarbamate

: 1361378-83-7
(S)-2-amino-N-((S)-1-benzylazepan-3-yl)-2-cyclohexylacetamide dihydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 1h;
DOI:10.1016/j.bmcl.2011.12.109

Reference yield:

: 635754-98-2
(S)-3-amino-1-benzylazepan-2-one hydrochloride

: 1361378-83-7
(S)-2-amino-N-((S)-1-benzylazepan-3-yl)-2-cyclohexylacetamide dihydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: borane-THF / tetrahydrofuran / 20 °C / Inert atmosphere

2.1: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.17 h / 0 °C

2.2: 0 - 20 °C

3.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; borane-THF; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.12.109

Reference yield:

: 100-39-0
benzyl bromide

: 1361378-83-7
(S)-2-amino-N-((S)-1-benzylazepan-3-yl)-2-cyclohexylacetamide dihydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / 0 °C

1.2: 20 °C

2.1: hydrogenchloride / 1,4-dioxane / 2.5 h / 20 °C

3.1: borane-THF / tetrahydrofuran / 20 °C / Inert atmosphere

4.1: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.17 h / 0 °C

4.2: 0 - 20 °C

5.1: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; borane-THF; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmcl.2011.12.109