tert-butyl (S)-2-((S)-1-benzylazepan-3-ylamino)-1-cyclohexyl-2-oxoethylcarbamate

Base Information

Chemical Name:tert-butyl (S)-2-((S)-1-benzylazepan-3-ylamino)-1-cyclohexyl-2-oxoethylcarbamate
CAS No.:1361323-03-6
Molecular Formula:C₂₆H₄₁N₃O₃
Molecular Weight:443.63
Hs Code.:

Synonyms:tert-butyl (S)-2-((S)-1-benzylazepan-3-ylamino)-1-cyclohexyl-2-oxoethylcarbamate

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Chemical Property of tert-butyl (S)-2-((S)-1-benzylazepan-3-ylamino)-1-cyclohexyl-2-oxoethylcarbamate

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Technology Process of tert-butyl (S)-2-((S)-1-benzylazepan-3-ylamino)-1-cyclohexyl-2-oxoethylcarbamate

There total 4 articles about tert-butyl (S)-2-((S)-1-benzylazepan-3-ylamino)-1-cyclohexyl-2-oxoethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 635754-98-2
(S)-3-amino-1-benzylazepan-2-one hydrochloride

: 1361323-03-6
tert-butyl (S)-2-((S)-1-benzylazepan-3-ylamino)-1-cyclohexyl-2-oxoethylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: borane-THF / tetrahydrofuran / 20 °C / Inert atmosphere

2.1: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.17 h / 0 °C

2.2: 0 - 20 °C

With 4-methyl-morpholine; borane-THF; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.12.109

Reference yield:

: 100-39-0
benzyl bromide

: 1361323-03-6
tert-butyl (S)-2-((S)-1-benzylazepan-3-ylamino)-1-cyclohexyl-2-oxoethylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / 0 °C

1.2: 20 °C

2.1: hydrogenchloride / 1,4-dioxane / 2.5 h / 20 °C

3.1: borane-THF / tetrahydrofuran / 20 °C / Inert atmosphere

4.1: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.17 h / 0 °C

4.2: 0 - 20 °C

With 4-methyl-morpholine; hydrogenchloride; borane-THF; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmcl.2011.12.109

Reference yield:

: 76944-95-1
tert-butyl N-[(3S)-2-oxoazepan-3-yl]carbamate

: 1361323-03-6
tert-butyl (S)-2-((S)-1-benzylazepan-3-ylamino)-1-cyclohexyl-2-oxoethylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / 0 °C

1.2: 20 °C

2.1: hydrogenchloride / 1,4-dioxane / 2.5 h / 20 °C

3.1: borane-THF / tetrahydrofuran / 20 °C / Inert atmosphere

4.1: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0.17 h / 0 °C

4.2: 0 - 20 °C

With 4-methyl-morpholine; hydrogenchloride; borane-THF; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmcl.2011.12.109