(S)-2-[4-[(2-Methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-2-(2,2,2-trifluoro-acetylamino)-benzoylamino]-pentanedioic acid diethyl ester

Base Information

Chemical Name:(S)-2-[4-[(2-Methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-2-(2,2,2-trifluoro-acetylamino)-benzoylamino]-pentanedioic acid diethyl ester
CAS No.:129175-53-7
Molecular Formula:C₃₁H₃₂F₃N₅O₇
Molecular Weight:643.62
Hs Code.:

(S)-2-[4-[(2-Methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-2-(2,2,2-trifluoro-acetylamino)-benzoylamino]-pentanedioic acid diethyl ester

Synonyms:(S)-2-[4-[(2-Methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-2-(2,2,2-trifluoro-acetylamino)-benzoylamino]-pentanedioic acid diethyl ester

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Chemical Property of (S)-2-[4-[(2-Methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-2-(2,2,2-trifluoro-acetylamino)-benzoylamino]-pentanedioic acid diethyl ester

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Technology Process of (S)-2-[4-[(2-Methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-2-(2,2,2-trifluoro-acetylamino)-benzoylamino]-pentanedioic acid diethyl ester

There total 6 articles about (S)-2-[4-[(2-Methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-2-(2,2,2-trifluoro-acetylamino)-benzoylamino]-pentanedioic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 129175-77-5
(S)-2-[4-Prop-2-ynylamino-2-(2,2,2-trifluoro-acetylamino)-benzoylamino]-pentanedioic acid diethyl ester

: 112888-43-4
4(3H)-oxo-6-(bromomethyl)-2-methyl quinazoline

: 129175-53-7
(S)-2-[4-[(2-Methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-2-(2,2,2-trifluoro-acetylamino)-benzoylamino]-pentanedioic acid diethyl ester

Guidance literature:: With 2,6-dimethylpyridine; In N,N-dimethyl-formamide; at 80 ℃; for 18h;
DOI:10.1021/jm00173a026

Reference yield:

: 1118-89-4
diethyl-L-glutamate hydrochloride

: 129175-53-7
(S)-2-[4-[(2-Methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-2-(2,2,2-trifluoro-acetylamino)-benzoylamino]-pentanedioic acid diethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N / CH₂Cl₂ / 1 h

2: H₂ / 10percent Pd/C / ethyl acetate / 4 h / 760 Torr

3: 62 percent / 2,6-lutidine / dimethylformamide / 9 h / 60 °C

4: 44 percent / 2,6-lutidine / dimethylformamide / 18 h / 80 °C

With 2,6-dimethylpyridine; hydrogen; triethylamine; palladium on activated charcoal; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00173a026

Reference yield:

: 91533-09-4
4-nitro-2-trifluoro-acetamido-benzoic acid

: 129175-53-7
(S)-2-[4-[(2-Methyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-2-(2,2,2-trifluoro-acetylamino)-benzoylamino]-pentanedioic acid diethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: oxalyl chloride, DMF / CH₂Cl₂ / 3 h

2: Et₃N / CH₂Cl₂ / 1 h

3: H₂ / 10percent Pd/C / ethyl acetate / 4 h / 760 Torr

4: 62 percent / 2,6-lutidine / dimethylformamide / 9 h / 60 °C

5: 44 percent / 2,6-lutidine / dimethylformamide / 18 h / 80 °C

With 2,6-dimethylpyridine; oxalyl dichloride; hydrogen; triethylamine; N,N-dimethyl-formamide; palladium on activated charcoal; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00173a026