4-methyl-N-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-N-[4-(methanesulfonyloxy)-2-butynyl]benzenesulfonamide

Base Information

• Chemical Name: 4-methyl-N-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-N-[4-(methanesulfonyloxy)-2-butynyl]benzenesulfonamide
• CAS No.: 1015445-13-2
• Molecular Formula: C₂₀H₃₃NO₆S₂Si
• Molecular Weight: 475.703
• Mol file: 1015445-13-2.mol

Synonyms:4-methyl-N-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-N-[4-(methanesulfonyloxy)-2-butynyl]benzenesulfonamide

Chemical Property of 4-methyl-N-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-N-[4-(methanesulfonyloxy)-2-butynyl]benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-methyl-N-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-N-[4-(methanesulfonyloxy)-2-butynyl]benzenesulfonamide

There total 1 articles about 4-methyl-N-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-N-[4-(methanesulfonyloxy)-2-butynyl]benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

N-(4-hydroxy-2-butynyl)-4-methyl-N-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]benzenesulfonamide (1015445-12-1) + methanesulfonyl chloride (124-63-0) → 4-methyl-N-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-N-[4-(methanesulfonyloxy)-2-butynyl]benzenesulfonamide (1015445-13-2)

Guidance literature:

With triethylamine; In dichloromethane; at -78 - 0 ℃; for 3h; Inert atmosphere;

DOI:10.1021/ol702966j

Reference yield: 90.0%

4-methyl-N-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-N-[4-(methanesulfonyloxy)-2-butynyl]benzenesulfonamide (1015445-13-2) + methyllithium (917-54-4) → 4-methyl-N-(2-methyl-2,3-butadienyl)-N-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]benzenesulfonylamide (1015445-14-3)

Guidance literature:

methyllithium; With copper(l) cyanide; lithium chloride; In tetrahydrofuran; diethyl ether; at 0 ℃; for 0.166667h; Inert atmosphere;

4-methyl-N-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-N-[4-(methanesulfonyloxy)-2-butynyl]benzenesulfonamide; In tetrahydrofuran; diethyl ether; at 0 ℃; for 1h; Inert atmosphere;

DOI:10.1021/ol702966j

Reference yield:

4-methyl-N-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-N-[4-(methanesulfonyloxy)-2-butynyl]benzenesulfonamide (1015445-13-2) + isobutylmagnesium bromide (926-62-5) → C23H39NO3SSi

Guidance literature:

isobutylmagnesium bromide; With copper(l) iodide; lithium bromide; In tetrahydrofuran; at -78 ℃; for 1h;

4-methyl-N-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-N-[4-(methanesulfonyloxy)-2-butynyl]benzenesulfonamide; In tetrahydrofuran; at -78 - 20 ℃; for 1h;

DOI:10.1246/bcsj.20190167

upstream raw materials:

N-(4-hydroxy-2-butynyl)-4-methyl-N-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]benzenesulfonamide

methanesulfonyl chloride

Downstream raw materials:

4-methyl-N-(2-methyl-2,3-butadienyl)-N-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]benzenesulfonylamide