1-(tert-butyldimethylsilyloxy)-2-(3-methoxymethyloxymethylphenyl)-2-(octanoylamino)ethyl

Base Information

Chemical Name:1-(tert-butyldimethylsilyloxy)-2-(3-methoxymethyloxymethylphenyl)-2-(octanoylamino)ethyl
CAS No.:532986-79-1
Molecular Formula:C₂₅H₄₅NO₄Si
Molecular Weight:451.722
Hs Code.:

Synonyms:1-(tert-butyldimethylsilyloxy)-2-(3-methoxymethyloxymethylphenyl)-2-(octanoylamino)ethyl

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(tert-butyldimethylsilyloxy)-2-(3-methoxymethyloxymethylphenyl)-2-(octanoylamino)ethyl

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Technology Process of 1-(tert-butyldimethylsilyloxy)-2-(3-methoxymethyloxymethylphenyl)-2-(octanoylamino)ethyl

There total 11 articles about 1-(tert-butyldimethylsilyloxy)-2-(3-methoxymethyloxymethylphenyl)-2-(octanoylamino)ethyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 107-30-2
chloromethyl methyl ether

: 532986-78-0
1-(tert-butyldimethylsilyloxy)-2-(3-hydroxymethylphenyl)-2-(octanoylamino)ethyl

: 532986-79-1
1-(tert-butyldimethylsilyloxy)-2-(3-methoxymethyloxymethylphenyl)-2-(octanoylamino)ethyl

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1016/S0968-0896(02)00381-4

Reference yield:

: 130697-96-0
methyl amino(3-hydroxyphenyl)acetate

: 532986-79-1
1-(tert-butyldimethylsilyloxy)-2-(3-methoxymethyloxymethylphenyl)-2-(octanoylamino)ethyl

Guidance literature:: Multi-step reaction with 9 steps

1: 88 percent / NaHCO₃ / tetrahydrofuran / 0.5 h / 0 °C

2: K₂CO₃ / acetone / 8 h / Heating

3: 79 percent / LiBH₄ / tetrahydrofuran / 18 h / 0 - 20 °C

4: 100 percent / imidazole / dimethylformamide / 18 h / 0 °C

5: 100 percent / H₂ / 10 percent Pd-C / methanol / 2 h / 20 °C / atmospheric pressure

6: 100 percent / pyridine / 1 h / 0 °C

7: 93 percent / Et₃N; Pd(OAc)2; DPPP / methanol; dimethylsulfoxide / 2 h / 20 - 70 °C

8: 62 percent / LiBH₄ / tetrahydrofuran; methanol / 22 h / 0 - 45 °C

9: 89 percent / i-Pr₂NEt / CH₂Cl₂ / 1 h / 20 °C

With 1H-imidazole; palladium diacetate; lithium borohydride; 1,3-bis-(diphenylphosphino)propane; hydrogen; sodium hydrogencarbonate; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; pyridine; methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone;
DOI:10.1016/S0968-0896(02)00381-4

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 532986-79-1
1-(tert-butyldimethylsilyloxy)-2-(3-methoxymethyloxymethylphenyl)-2-(octanoylamino)ethyl

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / imidazole / dimethylformamide / 18 h / 0 °C

2: 100 percent / H₂ / 10 percent Pd-C / methanol / 2 h / 20 °C / atmospheric pressure

3: 100 percent / pyridine / 1 h / 0 °C

4: 93 percent / Et₃N; Pd(OAc)2; DPPP / methanol; dimethylsulfoxide / 2 h / 20 - 70 °C

5: 62 percent / LiBH₄ / tetrahydrofuran; methanol / 22 h / 0 - 45 °C

6: 89 percent / i-Pr₂NEt / CH₂Cl₂ / 1 h / 20 °C

With 1H-imidazole; palladium diacetate; lithium borohydride; 1,3-bis-(diphenylphosphino)propane; hydrogen; triethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; pyridine; methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(02)00381-4