Technology Process of (E)-N-tert-butyl-3-(2,2-diphenylcyclopropyl)prop-2-en-1-amine
There total 9 articles about (E)-N-tert-butyl-3-(2,2-diphenylcyclopropyl)prop-2-en-1-amine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(E)-3-(2,2-diphenylcyclopropyl)prop-2-en-1-ol;
With
N-Bromosuccinimide; triphenylphosphine;
In
tetrahydrofuran;
at -20 ℃;
for 0.0833333h;
tert-butylamine;
In
tetrahydrofuran;
at 20 ℃;
DOI:10.1080/00397910600977574
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: 100 percent / hydrazine hydrate / ethanol / 12 h / Heating
2.1: yellow mercury(II) oxide / petroleum ether / 10 h / 20 °C
3.1: 3.23 g / petroleum ether / 4 h / 50 °C
4.1: 71 percent / lithium aluminium hydride / tetrahydrofuran / 2.5 h / Heating
5.1: 83 percent / o-iodoxybenzoic acid / ethyl acetate / 2 h / 80 °C
6.1: sodium hydride / various solvent(s); tetrahydrofuran / 0.5 h / 20 °C
6.2: 82 percent / tetrahydrofuran; various solvent(s) / 12 h / 20 °C
7.1: 100 percent / DIBAL-H / toluene; tetrahydrofuran / 3 h / -78 °C
8.1: N-bromosuccinimide; triphenylphosphine / tetrahydrofuran / 0.08 h / -20 °C
8.2: 91 percent / tetrahydrofuran / 20 °C
With
N-Bromosuccinimide; lithium aluminium tetrahydride; sodium hydride; diisobutylaluminium hydride; hydrazine hydrate; triphenylphosphine; mercury(II) oxide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione;
In
tetrahydrofuran; ethanol; ethyl acetate; toluene; Petroleum ether;
6.2: Horner-Wadsworth-Emmons reaction;
DOI:10.1080/00397910600977574
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 100 percent / DIBAL-H / toluene; tetrahydrofuran / 3 h / -78 °C
2.1: N-bromosuccinimide; triphenylphosphine / tetrahydrofuran / 0.08 h / -20 °C
2.2: 91 percent / tetrahydrofuran / 20 °C
With
N-Bromosuccinimide; diisobutylaluminium hydride; triphenylphosphine;
In
tetrahydrofuran; toluene;
DOI:10.1080/00397910600977574
