N-(2-(benzyloxy)-5-chlorophenyl)-1-(3-(4-methoxytetrahydro-2H-pyran-4-yl)phenyl)methane-sulfonamide

Base Information

Chemical Name:N-(2-(benzyloxy)-5-chlorophenyl)-1-(3-(4-methoxytetrahydro-2H-pyran-4-yl)phenyl)methane-sulfonamide
CAS No.:1289485-87-5
Molecular Formula:C₂₆H₂₈ClNO₅S
Molecular Weight:502.031
Hs Code.:

Synonyms:N-(2-(benzyloxy)-5-chlorophenyl)-1-(3-(4-methoxytetrahydro-2H-pyran-4-yl)phenyl)methane-sulfonamide

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Chemical Property of N-(2-(benzyloxy)-5-chlorophenyl)-1-(3-(4-methoxytetrahydro-2H-pyran-4-yl)phenyl)methane-sulfonamide

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Technology Process of N-(2-(benzyloxy)-5-chlorophenyl)-1-(3-(4-methoxytetrahydro-2H-pyran-4-yl)phenyl)methane-sulfonamide

There total 9 articles about N-(2-(benzyloxy)-5-chlorophenyl)-1-(3-(4-methoxytetrahydro-2H-pyran-4-yl)phenyl)methane-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1289485-31-9
(3-(4-methoxytetrahydro-2H-pyran-4-yl)phenyl)methanesulfonylchloride

: 6373-47-3
2-(benzyloxy)-5-chloroaniline

: 1289485-87-5
N-(2-(benzyloxy)-5-chlorophenyl)-1-(3-(4-methoxytetrahydro-2H-pyran-4-yl)phenyl)methane-sulfonamide

Guidance literature:: With sodium hydrogencarbonate; In dichloromethane;
DOI:10.1016/j.bmc.2011.01.043

Reference yield:

: 29943-42-8,143562-54-3
Tetrahydro-4H-pyran-4-one

: 1289485-87-5
N-(2-(benzyloxy)-5-chlorophenyl)-1-(3-(4-methoxytetrahydro-2H-pyran-4-yl)phenyl)methane-sulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: magnesium / tetrahydrofuran / Reflux

1.2: 1 h / Reflux

2.1: sodium hydride / tetrahydrofuran; mineral oil / 15 h / 20 °C

3.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 1.5 h / Reflux

4.1: sodium sulfite / ethanol; water / Reflux

4.2: 1.5 h / 20 °C

5.1: sodium hydrogencarbonate / dichloromethane

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium hydride; sodium hydrogencarbonate; magnesium; sodium sulfite; In tetrahydrofuran; tetrachloromethane; ethanol; dichloromethane; water; mineral oil;
DOI:10.1016/j.bmc.2011.01.043

Reference yield:

: 1289485-53-5
C₂₁H₁₄ClNO₃

: 1289485-87-5
N-(2-(benzyloxy)-5-chlorophenyl)-1-(3-(4-methoxytetrahydro-2H-pyran-4-yl)phenyl)methane-sulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: water; hydrazine / ethanol / 2 h / Reflux

2: sodium hydrogencarbonate / dichloromethane

With water; sodium hydrogencarbonate; hydrazine; In ethanol; dichloromethane;
DOI:10.1016/j.bmc.2011.01.043