6373-47-3

Usage

Uses

Used in Organic Synthesis:
2-(benzyloxy)-5-chlorobenzenamine is used as a key intermediate in the synthesis of various organic compounds due to its reactive functional groups, which allow for further chemical modifications and the creation of a wide range of molecules with diverse properties.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 2-(benzyloxy)-5-chlorobenzenamine is utilized as a starting material for the development of new drugs. Its unique structure and potential pharmacological properties make it a promising candidate for the design and synthesis of novel therapeutic agents.
Used in Drug Development:
2-(benzyloxy)-5-chlorobenzenamine is employed in drug development as a precursor for the creation of pharmaceuticals with potential therapeutic applications. Its presence in the molecular structure can influence the pharmacokinetics, pharmacodynamics, and overall efficacy of the resulting drug candidates.
Safety Considerations:

InChI:InChI=1/C16H14N4O2S/c1-22-13-9-5-8-12(10-13)17-15(21)18-16-20-19-14(23-16)11-6-3-2-4-7-11/h2-10H,1H3,(H2,17,18,20,21)

Upstream product

• 100-39-0 benzyl bromide 
• 345-18-6 2-fluoro-5-chloronitrobenzene 
• 100-51-6 benzyl alcohol 
• 80460-34-0 2-(5-chloro-2-hydroxy-phenyl)-isoindole-1,3-dione 
• 95-85-2 2-hydroxy-5-chloro-aniline 
• 1289485-53-5 C₂₁H₁₄ClNO₃ 
• 92044-52-5 1-(benzyloxy)-4-chloro-2-nitrobenzene 

Downstream Products

• 1289485-87-5 N-(2-(benzyloxy)-5-chlorophenyl)-1-(3-(4-methoxytetrahydro-2H-pyran-4-yl)phenyl)methane-sulfonamide 
• 1289485-97-7 N-(2-(benzyloxy)-5-chlorophenyl)-N-(3-(4-methoxytetrahydro-2H-pyran-4-yl)benzyl)methanesulfonamide 
• 1289485-68-2 N-(2-(benzyloxy)-5-chlorophenyl)methanesulfonamide 
• 1289486-06-1 2-(benzyloxy)-5-chloro-N-(3-(4-methoxytetrahydro-2H-pyran-4-yl)benzyl)aniline 
• 1451261-67-8 N-[2-(benzyloxy)-5-chlorophenyl]-1-benzofuran-2-sulfonamide 
• 850913-51-8 3-{1-[2-(benzyloxy)-5-chloro-phenyl]-5-methyl-1H-pyrrol-2-yl}-benzoic acid methyl ester 
• 850913-76-7 2-[1-(2-benzyloxy-5-chloro-phenyl)-5-methyl-1H-pyrrol-2-yl]-6-bromopyridine 
• 114508-05-3 5-chloro-2-(4-nitro-benzoyloxy)-2'-(4-nitro-benzoyloxymethyl)-biphenyl 
• 119338-10-2 2-chloro-6,6-diphenyl-6H-benzo[c]chromene 
• 90909-58-3 6H-2-chloro-dibenzopyran-6-one 
• 955953-73-8 2-(2-benzyloxy-5-chloro-phenylthiocarbamoyl)-2-cyano-acetamide 
• 22486-46-0 N-(2-Benzyloxy-5-chloro-phenyl)-N'-(2-methoxy-phenyl)-oxalamide 
• 1019-90-5 5-chloro-2-phenyl-1,3-benzoxazole 
• 124457-35-8 1-(2-benzyloxy-5-chlorophenyl)-4-(3-ethyl-1,2,4-oxadiazol-5-yl)-imidazole 

Relevant academic research and scientific papers

Discovery of a Potent Botulinum Neurotoxin A Inhibitor ZM299 with Effective Protections in Botulism Mice

Botulinum neurotoxins serotype A (BoNT/A) is the deadliest toxins known to humans and the "Category A" agent for bioterrorism. Over the past 20 years, significant efforts have been put forth to develop effective inhibitors of BoNT/A. Unfortunately, few id

MERCAPTONICOTINIC ACID COMPOUND AND PREPARATION METHOD AND USE THEREOF

The present invention discloses a class of mercaptonicotinic acid compound and preparation method and use thereof; the general structural formula of the compound is as shown in Formula I. Experiment demonstrates that the mercaptonicotinic acid compound co

BENZOFURAN-2-SULFONAMIDES DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS

The present invention relates to novel benzofuran-2-sulfonamide derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of chemokine receptors.

Syntheses and characterization of nimesulide derivatives for dual enzyme inhibitors of both cyclooxygenase-1/2 and 5-lipoxygenase

Cyclooxygenase-1/2 (COX-1/2) and 5-lipoxygenase (5-LOX) are enzymes in two different pathways in the inflammatory process. In the present study, a variety of new nimesulide derivatives were synthesized through incorporation of a 5-LOX pharmacophore into nimesulide followed with some structural modifications, which were then characterized for dual enzyme inhibitors for these two types of enzymes. Their structure-activity relationships (SARs) were studied, and compound 20f was found to be an excellent dual enzyme inhibitor. Its binding conformation and interaction mode were studied with molecular docking experiments. Compound 20f could become a lead compound for further development for potential anti-inflammatory drugs.

HETEROCYCLYL COMPOUNDS

Compounds of formula (I) or a pharmaceutically acceptable derivative thereof: wherein A, B, D, Z, R1, R2a , R2b, and Rx are as defined in the specification, a process for the preparation of such compounds, pharm