880-06-8Relevant academic research and scientific papers
Synthesis and antimicrobial activity of nitrobenzyl-oxy-phenol derivatives
Mohamed, Malik Suliman,Maki, Toshihide,Shah, Mohammad Monir,Ichinose, Yoshio
, p. 1888 - 1892 (2016/11/16)
Two hydroquinone derivatives were prepared and their antimicrobial activity evaluated. Their minimum inhibitory concentrations (MICs) were determined using a broth dilution method. Gentamycin and ciprofloxacin were used as reference antibiotics. The antimicrobial activity of 4-(benzyloxy)phenol (monobenzone) was also evaluated based on its structural similarity to the new compounds; activity was comparable to that of 3,5-dimethyl-4-((4-nitrobenzyl)oxy)phenol (4a). 2,3,5-Trimethyl-4-((4-nitrobenzyl)oxy)phenol (4b) exhibited the best antibacterial activity against both clinical isolates and type strain of Moraxella catarrhalis (M. catarrhalis), with a MIC value of 11 μM, comparable to ciprofloxacin 9 μM.
Hydroxylated analogs of mexiletine as tools for structural-requirements investigation of the sodium channel blocking activity
Catalano, Alessia,Carocci, Alessia,Cavalluzzi, Maria M.,Di Mola, Antonia,Lentini, Giovanni,Lovece, Angelo,Dipalma, Antonella,Costanza, Teresa,Desaphy, Jean-Francois,Camerino, Diana Conte,Franchini, Carlo
scheme or table, p. 325 - 332 (2011/07/29)
[2-(2-Aminopropoxy)-1,3-phenylene]dimethanol 1 and 4-(2-aminopropoxy)-3- (hydroxymethyl)-5-methylphenol 2, two dihydroxylated analogs of mexiletine - a well known class IB anti-arrhythmic drug - were synthesized and used as pharmacological tools to investigate the blockingactivity requirements of human skeletal muscle, voltage-gated sodium channel. The very low blocking activity shown by newly synthesized compounds corroborates the hypothesis that the presence of a phenolic group in the para-position to the aromatic moiety and/or benzylic hydroxyl groups on the aromatic moiety of local anesthetic-like drugs impairs either the transport to or the interaction with the binding site in the pore of Na+ channels.
Choice of Manganese(III) Complexes for the Synthesis of 4,4'-Biphenyldiols and 4,4'-Diphenoquinones
Nishino, Hiroshi,Nobuyuki, Itoh,Nagashima, Makiko,Kurosawa, Kazu
, p. 620 - 622 (2007/10/02)
2,6-Disubstituted phenols are oxidized with tris(2,4-pentanedionato)manganese(III), , in glacial acetic acid to give the corresponding 4,4'-biphenyldiols in high yields, whereas similar reactions using manganase(III) acetate, , instead of quantitatively yield the corresponding 4,4'-diphenoquinones.Cross-coupling reactions of 2,6-di-t-butylphenol and other substituted phenols afford the corresponding cross-coupled 4,4'-biphenyldiols and 4,4'-diphenoquinones together with oxidation products derived from them starting phenols themselves.The advantageous use of and Mn(OAc)3> in the ubiqitous phenol coupling reaction is discussed.
Experiments Directed Towards the Synthesis of Anthracyclinones. VII. Model Studies with Allyl Naphthalenyl Ethers
Boddy, Ian K.,Cambie, Richard C.,Dixon, Graham,Rutledge, Peter S.,Woodgate, Paul D.
, p. 803 - 813 (2007/10/02)
The Claisen rearrangement of some allyl naphthalen-1-yl ethers has been examined, together with methods for modification of the resulting 2-allyl side chain.Isomerisation of the C-allyl substituent to a prop-1-enyl group followed by ozonolysis gives a formyl derivative, while ozonolysis of a 2-(2-methylprop-2-enyl) moiety or mercuriation of a 2-(-2-chloroprop-2-enyl) substituent leads to an acetonyl derivative.Treatment of phenols with iodine(I) acetate and an excess of silver(I) acetate gives 4-hydroxyaryl acetates, probably via dienone intermediates.
