2-amino-2-(5-bromo-2-fluorophenyl)propanoic acid hydrochloride

Base Information

• Chemical Name: 2-amino-2-(5-bromo-2-fluorophenyl)propanoic acid hydrochloride
• CAS No.: 1374765-83-9
• Molecular Formula: C₉H₉BrFNO₂*ClH
• Molecular Weight: 298.539
• Mol file: 1374765-83-9.mol

Synonyms:2-amino-2-(5-bromo-2-fluorophenyl)propanoic acid hydrochloride

Chemical Property of 2-amino-2-(5-bromo-2-fluorophenyl)propanoic acid hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-amino-2-(5-bromo-2-fluorophenyl)propanoic acid hydrochloride

There total 2 articles about 2-amino-2-(5-bromo-2-fluorophenyl)propanoic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(5-bromo-2-fluorophenyl)ethan-1-one (198477-89-3) → 2-amino-2-(5-bromo-2-fluorophenyl)propanoic acid hydrochloride (1374765-83-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: ammonium hydroxide; ammonium chloride / water / 20 °C

1.2: Reflux

2.1: hydrogenchloride; water / Reflux

With hydrogenchloride; ammonium hydroxide; water; ammonium chloride; In water;

Reference yield:

rac-2-amino-2-(5-bromo-2-fluoro-phenyl)-propionitrile (1350523-51-1) → 2-amino-2-(5-bromo-2-fluorophenyl)propanoic acid hydrochloride (1374765-83-9)

Guidance literature:

With hydrogenchloride; water; Reflux;

Reference yield: 84.0%

2-amino-2-(5-bromo-2-fluorophenyl)propanoic acid hydrochloride (1374765-83-9) → (RS)-2-amino-2-(5-bromo-2-fluoro-phenyl)-propan-1-ol (1266784-24-0)

Guidance literature:

With sodium tetrahydroborate; boron trifluoride diethyl etherate; In tetrahydrofuran; at 0 - 25 ℃; for 3h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.0c02143

upstream raw materials:

1-(5-bromo-2-fluorophenyl)ethan-1-one

rac-2-amino-2-(5-bromo-2-fluoro-phenyl)-propionitrile

Downstream raw materials:

rac-2-amino-2-(5-bromo-2-fluoro-phenyl)-propionic acid methyl ester

(RS)-2-amino-2-(5-bromo-2-fluoro-phenyl)-propionic acid

(RS)-2-amino-2-(5-bromo-2-fluoro-phenyl)-propan-1-ol

2-(5-bromo-2-fluorophenyl)-2-(2-chloroacetylamino)propionic acid methyl ester