(E)-methyl (4-oxo-1-(2-(((triisopropylsilyl)oxy)methyl)phenyl)but-2-en-1-yl) carbonate

Base Information

• Chemical Name: (E)-methyl (4-oxo-1-(2-(((triisopropylsilyl)oxy)methyl)phenyl)but-2-en-1-yl) carbonate
• CAS No.: 1403749-58-5
• Molecular Formula: C₂₂H₃₄O₅Si
• Molecular Weight: 406.594
• Mol file: 1403749-58-5.mol

Synonyms:(E)-methyl (4-oxo-1-(2-(((triisopropylsilyl)oxy)methyl)phenyl)but-2-en-1-yl) carbonate

Chemical Property of (E)-methyl (4-oxo-1-(2-(((triisopropylsilyl)oxy)methyl)phenyl)but-2-en-1-yl) carbonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-methyl (4-oxo-1-(2-(((triisopropylsilyl)oxy)methyl)phenyl)but-2-en-1-yl) carbonate

There total 1 articles about (E)-methyl (4-oxo-1-(2-(((triisopropylsilyl)oxy)methyl)phenyl)but-2-en-1-yl) carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4,4-dimethoxy-but-2-enal (18778-96-6,4093-49-6) + methyl chloroformate (79-22-1) + ((2-bromobenzyl)oxy)triisopropylsilane (195624-82-9) → (E)-methyl (4-oxo-1-(2-(((triisopropylsilyl)oxy)methyl)phenyl)but-2-en-1-yl) carbonate (1403749-58-5)

Guidance literature:

((2-bromobenzyl)oxy)triisopropylsilane; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.583333h; Inert atmosphere;

4,4-dimethoxy-but-2-enal; In tetrahydrofuran; hexane; at -78 - 0 ℃; Inert atmosphere;

methyl chloroformate; In tetrahydrofuran; hexane; at 0 ℃; Inert atmosphere;

DOI:10.1002/anie.201204521

Reference yield: 79.0%

methanol (67-56-1) + (E)-methyl (4-oxo-1-(2-(((triisopropylsilyl)oxy)methyl)phenyl)but-2-en-1-yl) carbonate (1403749-58-5) → (R,E)-methyl 2-fluoro-4-(2-(((triisopropylsilyl)oxy)methyl)phenyl)but-3-enoate (1403749-26-7)

Guidance literature:

With (5aR,10bS)-5a,10b-dihydro-2-(2,4,6-trimethylphenyl)-4H,6H-indeno[2,1-b]-1,2,4-triazolo[4,3-d]-1,4-oxazinium chloride; sodium acetate; N-fluorobis(benzenesulfon)imide; In chloroform; at 20 ℃; for 48h; enantioselective reaction; Inert atmosphere;

DOI:10.1002/anie.201204521

upstream raw materials:

4,4-dimethoxy-but-2-enal

methyl chloroformate

((2-bromobenzyl)oxy)triisopropylsilane

Downstream raw materials:

(R,E)-methyl 2-fluoro-4-(2-(((triisopropylsilyl)oxy)methyl)phenyl)but-3-enoate