(R)-tert-butyl 3-(((benzyloxy)carbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoate

Base Information

Chemical Name:(R)-tert-butyl 3-(((benzyloxy)carbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoate
CAS No.:1407666-72-1
Molecular Formula:C₂₂H₂₄F₃NO₄
Molecular Weight:423.432
Hs Code.:

Synonyms:(R)-tert-butyl 3-(((benzyloxy)carbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoate

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Chemical Property of (R)-tert-butyl 3-(((benzyloxy)carbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoate

Chemical Property:

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Technology Process of (R)-tert-butyl 3-(((benzyloxy)carbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoate

There total 7 articles about (R)-tert-butyl 3-(((benzyloxy)carbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1407666-67-4
(R)-4-(t-butoxy)-4-oxo-2-(2,4,5-trifluorobenzyl)butanoic acid

: 100-51-6,185532-71-2
benzyl alcohol

: 1407666-72-1
(R)-tert-butyl 3-(((benzyloxy)carbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoate

Guidance literature:: (R)-4-(t-butoxy)-4-oxo-2-(2,4,5-trifluorobenzyl)butanoic acid; With diphenyl phosphoryl azide; triethylamine; In toluene; at 80 ℃; for 0.5h;

benzyl alcohol; In toluene; for 3h; Reflux;

Reference yield:

: 1407666-69-6
C₁₅H₁₆F₃NO₃

: 100-51-6,185532-71-2
benzyl alcohol

: 1407666-72-1
(R)-tert-butyl 3-(((benzyloxy)carbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoate

Guidance literature:: In toluene; for 3h; Reflux;

Reference yield:

: 651047-33-5
3-(2,4,5-trifluorophenyl)propanoic acid

: 1407666-72-1
(R)-tert-butyl 3-(((benzyloxy)carbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine; pivaloyl chloride; lithium chloride / tetrahydrofuran / -20 °C / Inert atmosphere

2.1: lithium hexamethyldisilazane / tetrahydrofuran / -40 °C / Inert atmosphere

3.1: water; lithium hydroxide; dihydrogen peroxide / tetrahydrofuran / 0 °C / Inert atmosphere

3.2: pH 1

4.1: triethylamine; diphenyl phosphoryl azide / toluene / 0.5 h / 80 °C

4.2: 3 h / Reflux

With diphenyl phosphoryl azide; water; dihydrogen peroxide; pivaloyl chloride; triethylamine; lithium chloride; lithium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; toluene; 4.1: Curtius Rearrangement;