(+/-)-N-(2-{[(4-fluorobenzyl)amino]carbonyl}-3-hydroxy-4-oxo-4,6,7,8,9,10-hexahydropyrimido[1,2-a]azepin-10-yl)-N,N',N'-trimethylethanediamide

Base Information

Chemical Name:(+/-)-N-(2-{[(4-fluorobenzyl)amino]carbonyl}-3-hydroxy-4-oxo-4,6,7,8,9,10-hexahydropyrimido[1,2-a]azepin-10-yl)-N,N',N'-trimethylethanediamide
CAS No.:724444-38-6
Molecular Formula:C₂₂H₂₆FN₅O₅
Molecular Weight:459.477
Hs Code.:

Synonyms:(+/-)-N-(2-{[(4-fluorobenzyl)amino]carbonyl}-3-hydroxy-4-oxo-4,6,7,8,9,10-hexahydropyrimido[1,2-a]azepin-10-yl)-N,N',N'-trimethylethanediamide

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Chemical Property of (+/-)-N-(2-{[(4-fluorobenzyl)amino]carbonyl}-3-hydroxy-4-oxo-4,6,7,8,9,10-hexahydropyrimido[1,2-a]azepin-10-yl)-N,N',N'-trimethylethanediamide

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Technology Process of (+/-)-N-(2-{[(4-fluorobenzyl)amino]carbonyl}-3-hydroxy-4-oxo-4,6,7,8,9,10-hexahydropyrimido[1,2-a]azepin-10-yl)-N,N',N'-trimethylethanediamide

There total 3 articles about (+/-)-N-(2-{[(4-fluorobenzyl)amino]carbonyl}-3-hydroxy-4-oxo-4,6,7,8,9,10-hexahydropyrimido[1,2-a]azepin-10-yl)-N,N',N'-trimethylethanediamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: C₁₈H₂₁FN₄O₃*ClH

: 32833-96-8
N,N-dimethyloxamic acid

: 541-41-3
chloroformic acid ethyl ester

: 724444-38-6
(+/-)-N-(2-{[(4-fluorobenzyl)amino]carbonyl}-3-hydroxy-4-oxo-4,6,7,8,9,10-hexahydropyrimido[1,2-a]azepin-10-yl)-N,N',N'-trimethylethanediamide

Guidance literature:: N,N-dimethyloxamic acid; chloroformic acid ethyl ester; With dmap; In tetrahydrofuran; at 0 - 5 ℃; for 2h;

C₁₈H₂₁FN₄O₃*ClH; In tetrahydrofuran; at 0 - 10 ℃; for 7h;

With hydrogenchloride; dimethyl amine; more than 3 stages;

Reference yield: 10.0%

: 724783-88-4
(+/-)-N-(4-fluorobenzyl)-3-hydroxy-10-(methylamino)-4-oxo-4,6,7,8,9,10-hexahydropyrimido[1,2-a]azepine-2-carboxamide

: 155129-30-9
potassium 2-(dimethylamino)-2-oxoacetate

: 724444-38-6
(+/-)-N-(2-{[(4-fluorobenzyl)amino]carbonyl}-3-hydroxy-4-oxo-4,6,7,8,9,10-hexahydropyrimido[1,2-a]azepin-10-yl)-N,N',N'-trimethylethanediamide

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In dichloromethane; at 20 ℃;
DOI:10.1021/jm701164t

Reference yield:

: C₁₈H₂₁FN₄O₃*ClH

: C₇H₁₁NO₅

: 724444-38-6
(+/-)-N-(2-{[(4-fluorobenzyl)amino]carbonyl}-3-hydroxy-4-oxo-4,6,7,8,9,10-hexahydropyrimido[1,2-a]azepin-10-yl)-N,N',N'-trimethylethanediamide

Guidance literature:: C₁₈H₂₁FN₄O₃*ClH; C₇H₁₁NO₅; With 4-methyl-morpholine; In tetrahydrofuran; at 0 - 10 ℃; for 7h;

With dimethyl amine; In tetrahydrofuran; water; at 10 - 15 ℃; for 1h;

With hydrogenchloride; In tetrahydrofuran; water; at 5 - 15 ℃; pH=3 - 4;