Technology Process of 2-butyl-1-<(2'-cyanobiphenyl-4-yl)methyl>-7-methyl-1H-benzimidazole
There total 9 articles about 2-butyl-1-<(2'-cyanobiphenyl-4-yl)methyl>-7-methyl-1H-benzimidazole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
Perbenzoic acid; tri-n-butyl-tin hydride;
In
toluene;
for 5.5h;
Heating;
DOI:10.1021/jm00064a011
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 78 percent / K2CO3 / dimethylformamide / 15 h / Ambient temperature
2: 90 percent / iron, conc. hydrochloric acid / methanol / 8 h / Heating
3: 93 percent / NaBH4, / methanol; tetrahydrofuran / 27 h / Heating
4: 92 percent / SO2Cl, DMF / CHCl3 / 1 h / Heating
5: 88 percent / tributyltin hydride, benzoyl peroxide / toluene / 5.5 h / Heating
With
hydrogenchloride; sodium tetrahydroborate; sulfuryl dichloride; Perbenzoic acid; tri-n-butyl-tin hydride; iron; potassium carbonate; N,N-dimethyl-formamide;
In
tetrahydrofuran; methanol; chloroform; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00064a011
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 28 percent / fuming nitric acid, acetic anhydride, conc. sulfuric acid / 4 h / Ambient temperature
2: 78 percent / K2CO3 / dimethylformamide / 15 h / Ambient temperature
3: 90 percent / iron, conc. hydrochloric acid / methanol / 8 h / Heating
4: 93 percent / NaBH4, / methanol; tetrahydrofuran / 27 h / Heating
5: 92 percent / SO2Cl, DMF / CHCl3 / 1 h / Heating
6: 88 percent / tributyltin hydride, benzoyl peroxide / toluene / 5.5 h / Heating
With
hydrogenchloride; sodium tetrahydroborate; sulfuryl dichloride; Perbenzoic acid; sulfuric acid; nitric acid; tri-n-butyl-tin hydride; acetic anhydride; iron; potassium carbonate; N,N-dimethyl-formamide;
In
tetrahydrofuran; methanol; chloroform; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00064a011