methyl 3-amino-4-(3,4-difluoroanilino)thieno[2,3-b]pyridine-2-carboxylate

Base Information

Chemical Name:methyl 3-amino-4-(3,4-difluoroanilino)thieno[2,3-b]pyridine-2-carboxylate
CAS No.:1292297-49-4
Molecular Formula:C₁₅H₁₁F₂N₃O₂S
Molecular Weight:335.334
Hs Code.:

Synonyms:methyl 3-amino-4-(3,4-difluoroanilino)thieno[2,3-b]pyridine-2-carboxylate

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Chemical Property of methyl 3-amino-4-(3,4-difluoroanilino)thieno[2,3-b]pyridine-2-carboxylate

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Technology Process of methyl 3-amino-4-(3,4-difluoroanilino)thieno[2,3-b]pyridine-2-carboxylate

There total 5 articles about methyl 3-amino-4-(3,4-difluoroanilino)thieno[2,3-b]pyridine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1292297-45-0
2-chloro-4-(3,4-difluoroanilino)pyridine-3-carbonitrile

: 2365-48-2
Methyl thioglycolate

: 1292297-49-4
methyl 3-amino-4-(3,4-difluoroanilino)thieno[2,3-b]pyridine-2-carboxylate

Guidance literature:: Methyl thioglycolate; With sodium methylate; In methanol; at 20 ℃; for 0.5h;

2-chloro-4-(3,4-difluoroanilino)pyridine-3-carbonitrile; In methanol; for 7h; Reflux;
DOI:10.1007/s11172-010-0338-2

Reference yield:

: 1292297-39-2
4-(3,4-difluoroanilino)-2-oxo-1,2-dihydropyridine-3-carbonitrile

: 1292297-49-4
methyl 3-amino-4-(3,4-difluoroanilino)thieno[2,3-b]pyridine-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine hydrochloride; trichlorophosphate / 6 h / Reflux

2.1: sodium methylate / methanol / 0.5 h / 20 °C

2.2: 7 h / Reflux

With sodium methylate; triethylamine hydrochloride; trichlorophosphate; In methanol;
DOI:10.1007/s11172-010-0338-2

Reference yield:

: 62321-92-0
α-cyano-β-dimethylaminocrotonamide

: 1292297-49-4
methyl 3-amino-4-(3,4-difluoroanilino)thieno[2,3-b]pyridine-2-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetic acid / 11 h / Reflux

2.1: ethanol / 8 h / Reflux

3.1: water; sodium hydroxide / ethanol / 1 h / Reflux

4.1: triethylamine hydrochloride; trichlorophosphate / 6 h / Reflux

5.1: sodium methylate / methanol / 0.5 h / 20 °C

5.2: 7 h / Reflux

With water; sodium methylate; triethylamine hydrochloride; acetic acid; sodium hydroxide; trichlorophosphate; In methanol; ethanol;
DOI:10.1007/s11172-010-0338-2