(E)-ethyl 2-(4-methoxyphenyl)-2-((trimethylsilyl)methylimino)acetate

Base Information

• Chemical Name: (E)-ethyl 2-(4-methoxyphenyl)-2-((trimethylsilyl)methylimino)acetate
• CAS No.: 1402841-27-3
• Molecular Formula: C₁₅H₂₃NO₃Si
• Molecular Weight: 293.438
• Mol file: 1402841-27-3.mol

Synonyms:(E)-ethyl 2-(4-methoxyphenyl)-2-((trimethylsilyl)methylimino)acetate

Chemical Property of (E)-ethyl 2-(4-methoxyphenyl)-2-((trimethylsilyl)methylimino)acetate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of (E)-ethyl 2-(4-methoxyphenyl)-2-((trimethylsilyl)methylimino)acetate

There total 1 articles about (E)-ethyl 2-(4-methoxyphenyl)-2-((trimethylsilyl)methylimino)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-trimethylsilylmethylamine (18166-02-4) + ethyl (p-methoxyphenyl)oxoacetate (40140-16-7) → (E)-ethyl 2-(4-methoxyphenyl)-2-((trimethylsilyl)methylimino)acetate (1402841-27-3)

Guidance literature:

With magnesium sulfate; In toluene; Inert atmosphere; Molecular sieve; Reflux;

DOI:10.1002/anie.201203828

Reference yield: 79.0%

N-phenyl-maleimide (941-69-5) + (E)-ethyl 2-(4-methoxyphenyl)-2-((trimethylsilyl)methylimino)acetate (1402841-27-3) → (1S,3aS,6aR)-ethyl 1-(4-methoxyphenyl)-4,6-dioxo-5-phenyloctahydropyrrolo[3,4-c]pyrrole-1-carboxylate (1402841-44-4)

Guidance literature:

With (R)-((4,4’-bi-1,3-benzodioxole)-5,5’-diyl)bis(bis(3,5-di-t-butyl-4-methoxyphenyl))phosphine; tetrakis(actonitrile)copper(I) hexafluorophosphate; In toluene; at 60 ℃; for 12h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1002/anie.201203828

upstream raw materials:

N-trimethylsilylmethylamine

ethyl (p-methoxyphenyl)oxoacetate

Downstream raw materials:

(1S,3aS,6aR)-ethyl 1-(4-methoxyphenyl)-4,6-dioxo-5-phenyloctahydropyrrolo[3,4-c]pyrrole-1-carboxylate