N-(2-chloro-6-methylphenyl)-2-cyanoacetamide

Base Information

Chemical Name:N-(2-chloro-6-methylphenyl)-2-cyanoacetamide
CAS No.:87165-28-4
Molecular Formula:C10H9 Cl N2 O
Molecular Weight:208.647
Hs Code.:
NSC Number:201563
DSSTox Substance ID:DTXSID70308040
Wikidata:Q82055698

Synonyms:N-(2-chloro-6-methylphenyl)-2-cyanoacetamide;87165-28-4;NSC201563;Oprea1_457511;DTXSID70308040;CCG-51728;MFCD00278454;STK317960;AKOS005138066;NSC-201563;CS-0367684;N-(2-chloro-6-methyl-phenyl)-2-cyano-acetamide;Acetamide, N-(2-chloro-6-methylphenyl)-2-cyano-;AP-970/43492200;SR-01000641012-1

Suppliers and Price of N-(2-chloro-6-methylphenyl)-2-cyanoacetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of N-(2-chloro-6-methylphenyl)-2-cyanoacetamide

Chemical Property:

Vapor Pressure:1.23E-06mmHg at 25°C
Boiling Point:400.8°C at 760 mmHg
Flash Point:196.2°C
Density:1.298g/cm³
XLogP3:1.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:208.0403406
Heavy Atom Count:14
Complexity:258

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C(=CC=C1)Cl)NC(=O)CC#N

Technology Process of N-(2-chloro-6-methylphenyl)-2-cyanoacetamide

There total 2 articles about N-(2-chloro-6-methylphenyl)-2-cyanoacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 105-56-6
ethyl 2-cyanoacetate

: 87-63-8
2-chloro-6-methylaniline

: 87165-28-4
N-(2-chloro-6-methylphenyl)-2-cyanoacetamide

Guidance literature:: In N,N-dimethyl-formamide; Heating;
DOI:10.1071/CH05286

Reference yield:

: 372-09-8
cyanoacetic acid

: 87-63-8
2-chloro-6-methylaniline

: 87165-28-4
N-(2-chloro-6-methylphenyl)-2-cyanoacetamide

Guidance literature:: cyanoacetic acid; 2-chloro-6-methylaniline; In tetrahydrofuran; at 0 ℃; Inert atmosphere;

With diisopropyl-carbodiimide; In tetrahydrofuran; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.1016/j.bmc.2008.02.046

Reference yield: 35.0%

: 87165-28-4
N-(2-chloro-6-methylphenyl)-2-cyanoacetamide

: 75-36-5
acetyl chloride

: N-((2-chloro-6-methyl)phenyl)-2-cyano-3-hydroxy-but-2-enamide

Guidance literature:: N-(2-chloro-6-methylphenyl)-2-cyanoacetamide; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere;

acetyl chloride; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

With acetic acid; In tetrahydrofuran; Inert atmosphere;
DOI:10.1016/j.bmc.2008.02.046