4-{[3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}benzaldehyde

Base Information

Chemical Name:4-{[3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}benzaldehyde
CAS No.:1374961-78-0
Molecular Formula:C₂₀H₁₇Cl₂NO₃
Molecular Weight:390.266
Hs Code.:

Synonyms:4-{[3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}benzaldehyde

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Chemical Property of 4-{[3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}benzaldehyde

Chemical Property:

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Technology Process of 4-{[3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}benzaldehyde

There total 5 articles about 4-{[3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 898253-47-9
4-(bromomethyl)-3-(2,6-dichlorophenyl)-5-isopropyl-isoxazole

: 123-08-0,65581-83-1
4-hydroxy-benzaldehyde

: 1374961-78-0
4-{[3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}benzaldehyde

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 3h;
DOI:10.1016/j.bmc.2012.03.016

Reference yield:

: 83-38-5
2,6-dichlorobenzaldehyde

: 1374961-78-0
4-{[3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}benzaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1: hydroxylamine hydrochloride; sodium hydroxide / ethanol; water / 12 h / 90 °C / Inert atmosphere

2: N-chloro-succinimide / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

3: sodium methylate / tetrahydrofuran; methanol / 12 h / 20 °C / Inert atmosphere

4: diisobutylaluminium hydride / tetrahydrofuran; toluene / 24 h / 0 - 20 °C / Inert atmosphere

5: triphenylphosphine; di-isopropyl azodicarboxylate / dichloromethane / 4 h / 20 °C / Inert atmosphere

With N-chloro-succinimide; di-isopropyl azodicarboxylate; hydroxylamine hydrochloride; sodium methylate; diisobutylaluminium hydride; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; 5: |Mitsunobu Displacement;
DOI:10.1021/acs.jmedchem.0c00618

Reference yield:

: 25185-95-9
2,6-dichlorobenzaldoxime

: 1374961-78-0
4-{[3-(2,6-dichlorophenyl)-5-isopropylisoxazol-4-yl]methoxy}benzaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: N-chloro-succinimide / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

2: sodium methylate / tetrahydrofuran; methanol / 12 h / 20 °C / Inert atmosphere

3: diisobutylaluminium hydride / tetrahydrofuran; toluene / 24 h / 0 - 20 °C / Inert atmosphere

4: triphenylphosphine; di-isopropyl azodicarboxylate / dichloromethane / 4 h / 20 °C / Inert atmosphere

With N-chloro-succinimide; di-isopropyl azodicarboxylate; sodium methylate; diisobutylaluminium hydride; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; 4: |Mitsunobu Displacement;
DOI:10.1021/acs.jmedchem.0c00618