(αS)-2,6-dibromo-α-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]benzenepropanol

Base Information

• Chemical Name: (αS)-2,6-dibromo-α-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]benzenepropanol
• CAS No.: 957212-54-3
• Molecular Formula: C₁₇H₁₄Br₂F₄O₂
• Molecular Weight: 486.099

Synonyms:(αS)-2,6-dibromo-α-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]benzenepropanol

Chemical Property of (αS)-2,6-dibromo-α-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]benzenepropanol

Chemical Property:

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Technology Process of (αS)-2,6-dibromo-α-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]benzenepropanol

There total 1 articles about (αS)-2,6-dibromo-α-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]benzenepropanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

3-(2,6-dibromo-phenyl)-1-[3-(1,1,2,2-tetrafluoroethoxy)-phenyl]-propan-1-one (957211-40-4) → (αS)-2,6-dibromo-α-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]benzenepropanol (957212-54-3)

Guidance literature:

3-(2,6-dibromo-phenyl)-1-[3-(1,1,2,2-tetrafluoroethoxy)-phenyl]-propan-1-one; With dimethylsulfide borane complex; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; at -15 ℃; for 0.833333h; Inert atmosphere;

With methanol; In tetrahydrofuran; at -20 ℃; optical yield given as %ee;

DOI:10.1021/ol900639j

Reference yield:

(αS)-2,6-dibromo-α-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]benzenepropanol (957212-54-3) + methanesulfonyl chloride (124-63-0) → C18H16Br2F4O4S

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/ol900639j

Reference yield:

(αS)-2,6-dibromo-α-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]benzenepropanol (957212-54-3) + R-(+)-α-trifluoromethyl-α-methoxy-phenylacetic acid (20445-31-2) → C27H21Br2F7O4

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 0.5h; Inert atmosphere;

DOI:10.1021/ol900639j

upstream raw materials:

3-(2,6-dibromo-phenyl)-1-[3-(1,1,2,2-tetrafluoroethoxy)-phenyl]-propan-1-one

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